Evidence map›Paper›PMID 42309057›Full record

ArticleCell host & microbe2026

The gut microbiota directs vitamin A flux to regulate intestinal T cell development.

Tarun Srinivasan, Chaitanya Dende, Kelly A Ruhn, Stefanie L Moye, Ann Johnson, Cassie L Behrendt, Brian Hassell, Gonçalo Vale, Jiwoong Kim, Jake N Lichterman and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Tarun SrinivasanDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chaitanya DendeDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kelly A RuhnDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Stefanie L MoyeMedical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ann JohnsonCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cassie L BehrendtDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Brian HassellDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Gonçalo ValeCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jiwoong KimDepartment of Public Health, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jake N LichtermanDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chaoying LiangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Carlos AranaDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Prithvi RajDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Xiaowei ZhanDepartment of Public Health, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jeffrey G McDonaldCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Andrew Y KohDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: andrew.koh@utsouthwestern.edu.
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: lora.hooper@utsouthwestern.edu.

Funding

Understanding the molecular mechanisms regulating fungal colonization and disease in the mammalian intestinal nicheP01AI179406 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TOBIAS M HOHL · 2024 to 2026
$9.9M
Microbial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Role of Gut Microbiota in Modulating Immune Checkpoint Inhibitory Therapy for CancerR01CA231303 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HOMSI, JADE, KOH, ANDREW · 2019 to 2023
$3.1M
Mentoring Patient Oriented Research in the Microbiome of Cancer and Stem Cell Transplant PatientsK24AI150992 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI KOH, ANDREW · 2020 to 2024
$592k
NCI NIH HHS R01 CA231303NIAID NIH HHS K24 AI150992NIAID NIH HHS P01 AI179406NIAID NIH HHS T32 AI007520NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK070855
6 · The paper itself

Abstract

The intestinal microbiota shapes adaptive immunity, but the mechanisms remain incompletely defined. Here, we show that the microbiota initiates movement of retinoids-dietary vitamin A derivatives including retinol and retinoic acid-through a sequential pathway from epithelial cells to myeloid cells and ultimately to T cells in the mesenteric lymph nodes (mLNs). This cellular axis is traversed over three days. Microbe-associated molecular patterns initiate retinoid flux by inducing expression of serum amyloid A proteins. These epithelial retinol-binding proteins are necessary and sufficient for epithelial-to-myeloid retinoid transfer and myeloid cell migration to the mLNs. In the mLNs, microbial antigen drives retinoid transfer from myeloid cells to developing T cells, culminating in T cell retinoid uptake and transcriptional programming. This pathway is activated during postnatal development, when gut adaptive immunity is established. These findings reveal that the microbiota programs intestinal adaptive immunity by regulating immune cell access to a nutrient-derived developmental signal.

Indexed as

Gastrointestinal MicrobiomeIntestinesT-LymphocytesVitamin AAdaptive ImmunityAnimalsCell MovementEpithelial CellsIntestinal MucosaLymph NodesMiceMice, Inbred C57BLMyeloid CellsRetinol-Binding ProteinsSerum Amyloid A ProteinTretinoinRetinol-Binding ProteinsSerum Amyloid A ProteinTretinoinVitamin ACD4+ T cellsintestinal homingmesenteric lymph nodesmicrobiotamyeloid cellspostnatal developmentRARretinoic acid receptorretinoidsserum amyloid Avitamin A

Identifiers

PMID42309057
PMCPMC13371082

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.