Evidence map›Paper›PMID 42308723›Full record

ArticleClinics (Sao Paulo, Brazil)2026

The impact of neonatal respiratory distress syndrome on subsequent preschool wheezing in very preterm infants: a multicenter cohort study.

Xiaoting Zhang, Yan Li, Xiaoyun Zhong, Lianfang Jing, Mingying Li, Xiangqun Zhao, Yuan Peng, Yuan Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoting ZhangDepartment of Neonatology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Municipal Health Commission Key Laboratory of Perinatal Medicine, Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health, Chongqing, China.
Yan LiNeonatal Medical Center, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, China.
Xiaoyun ZhongDepartment of Neonatology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Municipal Health Commission Key Laboratory of Perinatal Medicine, Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health, Chongqing, China.
Lianfang JingNeonatal Medical Center, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, China.
Mingying LiDepartment of Neonatology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Municipal Health Commission Key Laboratory of Perinatal Medicine, Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health, Chongqing, China.
Xiangqun ZhaoDepartment of Neonatology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Municipal Health Commission Key Laboratory of Perinatal Medicine, Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health, Chongqing, China.
Yuan PengDepartment of Neonatology, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Municipal Health Commission Key Laboratory of Perinatal Medicine, Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health, Chongqing, China.
Yuan ShiDepartment of Neonatology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders; China International Science and Technology Cooperation base of Child development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Chongqing, China. Electronic address: petshi530@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis multicenter cohort study investigated the association between neonatal Respiratory Distress Syndrome (RDS) and wheezing in preschool-aged preterm infants.

methodsA total of 525 children born at < 32-weeks' gestation were enrolled from three tertiary hospitals in Southwest China and classified into RDS (n = 275) and non-RDS (n = 250) groups. Current wheezing (≥ 1 parental-reported episode in the past year) outcomes were assessed using the International Study on Asthma and Allergy in Childhood (ISAAC) questionnaire at 3-6 years of age.

resultsThe RDS group showed a significantly higher incidence of current wheezing (11.3% vs. 5.6%; aOR = 2.45, 95% CI 1.20-4.98). Subgroup analyses revealed particularly elevated risks among females, infants born at 28⁺⁰-29⁺⁶ weeks, those with birth weights of 1000-1499g, non-IVF conceptions, those with bronchopulmonary dysplasia, and those with < 14-days of oxygen therapy. Sensitivity analyses supported the robustness of these findings.

conclusionsThe study indicates that RDS is an independent risk factor for wheezing in preterm preschoolers and highlights the need for targeted respiratory monitoring in this population.

Indexed as

Cohort studyPreschool childrenRespiratory distress syndromeVery preterm infantsWheezing

Identifiers

PMID42308723
PMCPMC13293732

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.