Trial reportThe New England journal of medicine2026
Cefazolin for Methicillin-Susceptible
Abstract readClinical Trial, Phase IVComparative StudyEquivalence Trial
In one paragraph
Trial report in The New England journal of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- ADVANCE-ID bacterial and fungal infections review: antimicrobial resistance research updates.JAC-antimicrobial resistance · 2026Article
- Cefazolin Versus Antistaphylococcal Penicillins in Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2026Review
- Acute kidney injury in Staphylococcus aureus bacteraemia: a multicentre cohort study of incidence, timing, recovery and associations with antibiotic treatment.The Journal of antimicrobial chemotherapy · 2026Article
- Cefazolin Versus Flucloxacillin for Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2026Article
- A review of the randomized clinical trial results from the Staphylococcus aureus network adaptive platform (SNAP) meticillin-susceptible (MSSA) and penicillin-susceptible (PSSA) domains and CloCeBa.The Journal of antimicrobial chemotherapy · 2026Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
239 authors.
Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group
Todd C LeeDepartment of Medicine, Division of Infectious Diseases, McGill University, Montreal.ORCID 0000-0002-2267-4239
Lauren A BarinaDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Genevieve WallsDepartment of Infectious Diseases, Division of Medicine, Middlemore Hospital, Auckland, New Zealand.
Anna L GoodmanUniversity College London Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London.
Dafna YahavInfectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel.
Matthew P ChengDepartment of Medicine, Division of Infectious Diseases, McGill University, Montreal.
Marc BontenEpidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center (UMC) Utrecht, Utrecht University, Utrecht, the Netherlands.
Asha C BowenWesfarmers Centre of Vaccines and Infectious Diseases, Kids Research Institute Australia, Nedlands, WA, Australia.ORCID 0000-0002-3242-1155
Tom BoylesClinical HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.
Nick DanemanDepartment of Medicine, Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto.
Miquel B EkkelenkampDepartment of Medical Microbiology, Division of Laboratories, Pharmacy, and Biomedical Genetics, UMC Utrecht, Utrecht, the Netherlands.
Nesrin Ghanem-ZoubiInfectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.
Marjolein P M HensgensDepartment of Infectious Diseases, UMC Utrecht, Utrecht University, Utrecht, the Netherlands.
Nynke G L JagerDepartment of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands.
Achim J KaaschMedical Faculty of the Otto von Guericke University Magdeburg, Institute of Medical Microbiology and Hospital Hygiene, Magdeburg, Germany.ORCID 0000-0002-6659-6738
Ilse J E KouijzerDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Roger J LewisBerry Consultants, Austin, TX.
Thomas LumleyDepartment of Statistics, University of Auckland, Auckland, New Zealand.
David C LyeNational Centre for Infectious Diseases, Tan Tock Seng Hospital, Singapore.
Emily G McDonaldDepartment of Medicine, Division of General Internal Medicine, Research Institute of the McGill University Health Centre, Montreal.
Genevieve McKewDepartment of Microbiology and Infectious Diseases, Concord Repatriation and General Hospital, New South Wales Health Pathology, Concord, NSW, Australia.
Alistair R D McLeanCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Brendan J McMullanFaculty of Medicine and Health, University of New South Wales, Sydney.
Zoe K McQuiltenSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Susan C MorpethDepartment of Infectious Diseases, Division of Medicine, Middlemore Hospital, Auckland, New Zealand.
David L PatersonAdvancing Clinical Evidence in Infectious Diseases (ADVANCE-ID), Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Jason A RobertsUniversity of Queensland Centre for Clinical Research, Faculty of Health, Medicine, and Behavioural Sciences, University of Queensland, Brisbane, Australia.
J Owen RobinsonDepartment of Infectious Diseases, Royal Perth Hospital, Perth, WA, Australia.
Hiroki SaitoDepartment of Emergency and Critical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Matthew ScarboroughDepartment of Infectious Diseases, Medical Research Council, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Jaap Ten OeverDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Rebecca M TurnerUniversity College London Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London.
Jonas TverringDepartment of Clinical Sciences Lund-Clinical Sciences Helsingborg, Faculty of Medicine, Infection Medicine, Lund University, Helsingborg, Sweden.
Sebastiaan J van HalDepartment of Infectious Diseases and Microbiology, New South Wales Health Pathology, Royal Prince Alfred Hospital, Sydney.
Steve A WebbAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.
Lynda M WhitewayDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Cesar A AriasInternal Medicine, Infectious Diseases, Houston Methodist and Weill Cornell Medical College, Houston.ORCID 0000-0001-9054-9774
Andrew HendersonInfection Management Services, Princess Alexandra Hospital, Brisbane, QLD, Australia.
George S HeriotDepartment of Infectious Diseases, Melbourne Medical School, University of Melbourne, Parkville, VIC, Australia.
Tom L SnellingSchool of Public Health, University of Sydney, Camperdown, NSW, Australia.
Kevin AfraDepartment of Medicine, Division of Infectious Diseases, Fraser Health, Surrey, BC, Canada.
Shabinah S AliUniversity College London Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London.
Sharon AmitFaculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Nicholas A AnagnostouMicrobiology and Infectious Diseases, Medicine, Cardiac and Critical Care, Southern Adelaide Local Health Network, Bedford Park, SA, Australia.
Sophia ArchuletaDepartment of Medicine, Division of Infectious Diseases, National University Hospital, Singapore.
Stephen J AstonTropical and Infectious Diseases Unit, University Hospitals of Liverpool Group, Liverpool, United Kingdom.
Eugene AthanDepartment of Infectious Diseases, School of Medicine, Centre for Innovation in Infectious Disease and Immunology Research, Deakin University, Geelong, VIC, Australia.
Nadav BaharavInfectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel.
Anthony D BaiDepartment of Medicine, Division of Infectious Diseases, Queen's University, Kingston, ON, Canada.
Bridget E BarberDepartment of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Abinayah BaskaranUniversity College London Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London.
Michelle M A BerkeleyInfection Research, Infection Division, Medicine Board, University College London Hospitals NHS Foundation Trust, London.
Emma J BestDepartment of Paediatric Infectious Diseases, Starship Children's Hospital, Auckland, New Zealand.
Nilesh R BhilaveGoulburn Valley Hospital, Shepparton, VIC, Australia.
Max G BloomfieldInfection Services, Te Whatu Ora, Capital, Coast, Hutt Valley, and Wairarapa, Wellington, New Zealand.
Katherine A BondDepartment of Microbiology, Royal Melbourne Hospital, Parkville, VIC, Australia.
Jennifer BostockCare Policy and Evaluation Centre, London School of Economics and Political Science, London.
Carly L BotherasDepartment of Infectious Diseases, School of Medicine, Centre for Innovation in Infectious Disease and Immunology Research, Deakin University, Geelong, VIC, Australia.
Mark A BoydSchool of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.
Sophia M E BradshawUniversity College London Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London.
Elizabeth J BriggsDepartment of Critical Care Medicine, Te Toka Tumai Auckland City Hospital, Auckland, New Zealand.
Philip N BrittonDepartment of Infectious Diseases and Microbiology, Children's Hospital at Westmead, Westmead, NSW, Australia.
Anita J CampbellWesfarmers Centre of Vaccines and Infectious Diseases, Kids Research Institute Australia, Nedlands, WA, Australia.
Beau Z CarrDepartment of Infectious Diseases, Medicine, Eastern Health, Box Hill, VIC, Australia.
James A ChancellorInfection Services, Te Whatu Ora, Capital, Coast, Hutt Valley, and Wairarapa, Wellington, New Zealand.
Kevin ChenInfectious Diseases, Tauranga Hospital, Tauranga, New Zealand.
Elaine Y CheongDepartment of Microbiology and Infectious Diseases, Concord Repatriation and General Hospital, New South Wales Health Pathology, Concord, NSW, Australia.
Ka Lip ChewDepartment of Laboratory Medicine, Division of Microbiology, National University Hospital, Singapore.
Po Ying ChiaDepartment of Infectious Diseases, National Centre for Infectious Diseases, Singapore.
Rispah ChombaDivision of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.ORCID 0000-0003-3147-6688
Brian S W ChongDepartment of Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia.
Chris J N ClewsInfection Services, Te Whatu Ora, Capital, Coast, Hutt Valley, and Wairarapa, Wellington, New Zealand.
Jonathan M CohenDepartment of Paediatric Immunology and Infectious Diseases, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
Robert J CommonsGeneral and Subspecialty Medicine, Grampians Health Ballarat, Ballarat, VIC, Australia.
Tim CutfieldDepartment of Infectious Diseases, Division of Medicine, Middlemore Hospital, Auckland, New Zealand.
Peter DaleyInfectious Diseases, Memorial University of Newfoundland, St. John's, Canada.
Diane S DanielDepartment of Microbiology and Immunology, Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Jane DaviesGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.
Partha DeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Justin T DenholmVictorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia.
Mia Di VirgilioDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Yael Dishon-BenattarInfectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.
Ravindra DotelDepartment of Infectious Diseases, Blacktown Hospital, Sydney.
Erick H DuanDepartment of Medicine, Division of Critical Care, McMaster University, St. Catharines, ON, Canada.
Nicholas EasomInfection Research Group, Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom.
Noa Eliakim-RazInternal Medicine E, Unit of Infectious Diseases, Rabin Medical Center, Beilinson Campus, Petach-Tikvah, Israel.
Michelle M EnglandDepartment of Infectious Diseases, Fiona Stanley Hospital, Murdoch, WA, Australia.
Mark FahmyDepartment of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Aidan R FindlaterDepartment of Medicine, Division of Infectious Diseases, McMaster University, Hamilton, ON, Canada.
Katie L FlanaganSchool of Medicine, University of Tasmania, Hobart, Australia.
Ethan Z J FooDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Hong FooDepartment of Microbiology and Infectious Diseases, New South Wales Health Pathology, Liverpool Hospital, Sydney.
Daniel P ForsterDepartment of Infectious Diseases, Medicine, Eastern Health, Box Hill, VIC, Australia.
Michael FralickDivision of General Internal Medicine, Sinai Health, University of Toronto, Toronto.
Jaimie L FrazerDepartment of Infectious Diseases, Division of Medicine, Launceston General Hospital, Launceston, TAS, Australia.
Andrew P Gador-WhyteDepartment of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia.
Katherine GarnhamDepartment of Infectious Diseases, Gold Coast University Hospital, Southport, QLD, Australia.
Greg J GermanDepartment of Laboratory Medicine, Division of Microbiology, St. Joseph's Health Centre, Unity Health Toronto, Toronto.
Niladri GhoshDepartment of Infectious Diseases, Wollongong Public Hospital, Wollongong, NSW, Australia.
Elisabeth H GisolfInfectieziekten, Interne Geneeskunde, Rijnstate Ziekenhuis, Arnhem, the Netherlands.
Stefano G GiulieriVictorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia.
Susan R GouldingDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Jennifer M GrantInternal Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada.
Daniel GregsonDepartment of Medicine, Division of Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Kate C GrimwadeInfectious Diseases, Tauranga Hospital, Tauranga, New Zealand.
Mordechai GrupperInfectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.
Stephen D GuyDepartment of Infectious Diseases, Medicine, Eastern Health, Box Hill, VIC, Australia.
Amanda GweeAntimicrobials Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Victoria G HallDepartment of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0001-9353-0059
Erica J HardyDepartment of Medicine, Infectious Disease Service, Women and Infants Hospital, Providence, RI.
David J HarrisDepartment of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada.
James HatcherDepartment of Microbiology and Virology, Great Ormond Street Hospital for Children, London.
Mark R HobbsAdult Infectious Diseases, Te Toka Tumai Auckland City Hospital, Auckland, New Zealand.
Natasha E HolmesDepartment of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia.
Benjamin P HowdenDepartment of Microbiology and Immunology, Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0003-0237-1473
Paul J HugganDepartment of Infectious Disease, Waikato Hospital, Hamilton, New Zealand.
Zoe A JenningsDepartment of Infectious Diseases, Division of Medicine, Nepean Hospital, University of Sydney, Kingswood, NSW, Australia.
Jennie JohnstoneDepartment of Medicine, Division of Infectious Diseases, University of Toronto, Toronto.
Thomas JuniperDepartment of Infection, Guy's and St. Thomas' NHS Foundation Trust, London.
Shirin KalimuddinDepartment of Infectious Diseases, Singapore General Hospital, Singapore.
Musaiwale KamfoseResearch, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Christopher KandelDepartment of Medicine, Division of Infectious Diseases, Michael Garron Hospital, Toronto.
Matthew J KellyDepartment of Medicine, Hutt Hospital, Lower Hutt, New Zealand.
Robert A KozakBiological Sciences Platform, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto.
Michelle KüminExperimental Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Francois LamontagneDepartment of Medicine, Division of Internal Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Jillian S Y LauDepartment of Infectious Diseases, Monash Health, Clayton, VIC, Australia.
Ivor Russel LeeSingapore Infectious Disease Clinical Research Network, National Centre for Infectious Diseases, Singapore.
Ray J LinDepartment of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
Daisy LindsayDepartment of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Martin J LlewelynDepartment of Global Health and Infection, Brighton and Sussex Medical School, Falmer, United Kingdom.
Yves LongtinDivision of Infectious Diseases, Jewish General Hospital, Montreal.
Sylvain A LotherDepartment of Internal Medicine, Section of Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Christopher E LueyDepartment of Infectious Diseases, Division of Medicine, Middlemore Hospital, Auckland, New Zealand.
Derek R MacFaddenDivision of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Andrew A MahonyDepartment of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia.ORCID 0000-0002-9027-5539
Catherine MaldenInfectious Diseases Unit, Flinders Medical Centre, Adelaide, SA, Australia.
Isabelle MalhaméDepartment of Medicine, Division of General Internal Medicine, Centre for Outcomes Research and Evaluation, McGill University Health Centre, Montreal.
Laurens A ManningDepartment of Infectious Diseases, Fiona Stanley Hospital, Murdoch, WA, Australia.
Michael MarksClinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London.ORCID 0000-0002-7585-4743
Leslie J MartinDepartment of Medicine, Division of General Internal Medicine, McMaster University, Montreal.
Gail V MatthewsDepartment of Infectious Diseases, St. Vincent's Hospital, Sydney.
Patrick H McGannDepartment of Infectious Disease, Waikato Hospital, Hamilton, New Zealand.
James H McMahonDepartment of Infectious Diseases, Alfred Hospital, Melbourne, VIC, Australia.
Alexandra MelonDepartment of Infectious Diseases, Division of Medicine, Sunshine Coast University Hospital, Birtinya, QLD, Australia.
Vidthiya MenonDepartment of Infectious Diseases, Division of Medicine, Nepean Hospital, University of Sydney, Kingswood, NSW, Australia.
Dominik MertzDepartment of Medicine, Division of Infectious Diseases, McMaster University, Hamilton, ON, Canada.
Michael P MeyerKidz First Children's Hospital, Middlemore Hospital, Health New Zealand, Counties Manukau, Auckland, New Zealand.
James S MoltonDepartment of Infectious Diseases, Western Health, Footscray, VIC, Australia.
Jocelyn M MoraDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Ed MoranDepartment of Infectious Disease, Division of Medicine, North Bristol NHS Trust, Bristol, United Kingdom.
Leanne M MortimerDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Satwik MotaganahalliDepartment of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia.
Matthew P MullerDepartment of Medicine, Division of Infectious Diseases, University of Toronto, Toronto.
Alasdair P S MunroSchool of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-4317-0742
Fionnuala A MurrayDepartment of Infectious Diseases, Fiona Stanley Hospital, Murdoch, WA, Australia.
Srinivas MurthyDepartment of Pediatrics, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-9476-839X
Vanathi NagendraDepartment of Microbiology and Infectious Diseases, New South Wales Health Pathology, Liverpool Hospital, Sydney.
Henco NelDepartment of Infectious Diseases, Fiona Stanley Hospital, Murdoch, WA, Australia.
David W J NewDepartment of Infectious Diseases, Armadale Hospital, Mount Nasura, WA, Australia.
Vi NguyenDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Grace NortonSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Katherine M NortonDepartment of Infectious Diseases, Royal Perth Hospital, Perth, WA, Australia.
Clare B NourseInfectious Diseases, Queensland Children's Hospital, Brisbane, Australia.
Clemency J S NyeDepartment of Infectious Diseases, Cardiff and Vale University Health Board, Cardiff, United Kingdom.
Kevin O'CallaghanDepartment of Infectious Diseases, Redcliffe Hospital, Redcliffe, QLD, Australia.
Matthew V N O'SullivanCentre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia.
Sean W X OngDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Akaninyene A OtuInfection Research Group, Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom.
Melissa OwenDepartment of Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia.
Jesse PapenburgDivision of Infectious Diseases, Montreal Children's Hospital, McGill University Health Centre, Montreal.
Leighanne O ParkesDepartment of Medicine, Division of Infectious Diseases, McGill University, Montreal.
Mical PaulInfectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.
Santiago Perez-PatrigeonDepartment of Medicine, Division of Infectious Diseases, Queen's University, Kingston, ON, Canada.
Neta PetersielDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Lina PetrellaDepartment of Medicine, Division of Infectious Diseases, Research Institute of the McGill University Health Centre, Montreal.
Sarah L PettUniversity College London Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London.
David PhamCentre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia.
Chiara J PiazzeseDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Sebastien PoulinCentre Intégré de Santé et de Services Sociaux (CISSS) des Laurentides, Hôpital de St-Jérôme, Unité de Recherche Clinique du CISSS des Laurentides, St-Jérôme, QC, Canada.
Renata RehakDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Elissa Rennert-MayDepartment of Medicine, Division of Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Alexander J RichardsInfection Research Group, Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom.
Benjamin A RogersDepartment of Infectious Diseases, Monash Health, Clayton, VIC, Australia.
Euna SahngInfectious Diseases, Tauranga Hospital, Tauranga, New Zealand.
Brenda SaladaDepartment of Medicine, Division of Infectious Diseases, National University Hospital, Singapore.
Oded ScheuermanFaculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Kellie SchneiderDepartment of Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia.
Thomas R SchulzGoulburn Valley Hospital, Shepparton, VIC, Australia.
Kevin L SchwartzDepartment of Medicine, Division of Infectious Diseases, St. Joseph's Health Centre, Unity Health Toronto, Toronto.
Peter A SimosDepartment of Infectious Diseases, Gold Coast University Hospital, Southport, QLD, Australia.
Harsimran SinghDepartment of Infectious Diseases, Division of Medicine, Launceston General Hospital, Launceston, TAS, Australia.
Fleur S SinkelerDepartment of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands.
Simon SmithDepartment of Medicine, Cairns Hospital, Cairns, QLD, Australia.
Benjamin J SmithDepartment of Infectious Diseases, Western Health, Footscray, VIC, Australia.
Stephanie W SmithDepartment of Medicine, Division of Infectious Diseases, University of Alberta, Edmonton, Canada.
Ranjani SomayajiDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Christine SommervilleDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Rima X J SongDepartment of Infectious Diseases, Division of Medicine, Middlemore Hospital, Auckland, New Zealand.
David C SowdenDepartment of Infectious Diseases, Division of Medicine, Sunshine Coast University Hospital, Birtinya, QLD, Australia.
Michael J StarkRobinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Neil R H StoneDivision of Infection, University College London Hospitals, London.
Tobias StrunkNeonatal Directorate, Child and Adolescent Health Service, Perth, WA, Australia.
Archana SudDepartment of Infectious Diseases, Division of Medicine, Nepean Hospital, University of Sydney, Kingswood, NSW, Australia.
Khine P SweDepartment of Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia.
Caitlin R SymonsWesfarmers Centre of Vaccines and Infectious Diseases, Kids Research Institute Australia, Nedlands, WA, Australia.
Yen Ee TanDepartment of Microbiology, Singapore General Hospital, Singapore.
Thijs Ten DoesschateDepartment of Internal Medicine, Jeroen Bosch Hospital, s-Hertogenbosch, the Netherlands.
Siew Yee ThienDepartment of Infectious Diseases, Division of Medicine, Singapore General Hospital, Singapore.
Ashmitha ThomasDepartment of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia.
Mohamad-Ali TradDepartment of Infectious Diseases, Division of Medicine, Launceston General Hospital, Launceston, TAS, Australia.
Adrian R TramontanaDepartment of Infectious Diseases, Western Health, Footscray, VIC, Australia.
Jennifer L Y TsangNiagara Health Knowledge Institute, Niagara Health, St. Catharines, ON, Canada.
Kimberly UlettDepartment of General Medicine, Gold Coast Hospital and Health Service, Southport, QLD, Australia.
Jonathan UnderwoodDepartment of Infectious Diseases, Cardiff and Vale University Health Board, Cardiff, United Kingdom.
Berend J van WelzenDepartment of Infectious Diseases, UMC Utrecht, Utrecht University, Utrecht, the Netherlands.
Gloria Vazquez-GrandeDepartment of Internal Medicine, Section of Critical Care Medicine, University of Manitoba, Winnipeg, Canada.ORCID 0000-0001-5866-1045
Diana C Velasquez ReyesVictorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, VIC, Australia.
Janneke D M VerberkEuropean Clinical Research Alliance on Infectious Diseases (Ecraid), Utrecht, the Netherlands.
Lesley M VossDepartment of Paediatric Infectious Diseases, Starship Children's Hospital, Auckland, New Zealand.
Denise WardUniversity College London Innovative Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London.
Rachel H WebbDepartment of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Timothy J WhitmoreDepartment of Infectious Diseases, Royal Perth Hospital, Perth, WA, Australia.
Anat Wieder-FinesodInfectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel.
Heather L WilsonDepartment of Infectious Diseases and Clinical Microbiology, Division of Medicine, Canberra Hospital, Canberra, ACT, Australia.
Evan W WilsonDepartment of Medicine, Division of Infectious Diseases, Queen's University, Kingston, ON, Canada.
Hei Man WongDepartment of Infectious Diseases, Division of Medicine, Singapore General Hospital, Singapore.ORCID 0000-0003-2456-0873
Kate Wong SheGrants, Aotearoa Clinical Trials, Auckland, New Zealand.
Terence WuerzDepartment of Internal Medicine, Section of Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Deborah L YamamuraDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Alastair YeohTropical and Infectious Diseases Unit, University Hospitals of Liverpool Group, Liverpool, United Kingdom.
Boris Long Hei YowDepartment of Infectious Diseases, Division of Medicine, Middlemore Hospital, Auckland, New Zealand.
Michael DymockWesfarmers Centre of Vaccines and Infectious Diseases, Kids Research Institute Australia, Nedlands, WA, Australia.
Robert K MaharMelbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.
Anna McGlothlinStatistics, Berry Consultants, Austin, TX.ORCID 0000-0002-9079-6166
Julie A MarshWesfarmers Centre of Vaccines and Infectious Diseases, Kids Research Institute Australia, Nedlands, WA, Australia.
Joshua S DavisDepartment of Infectious Diseases, John Hunter Hospital, Newcastle, NSW, Australia.
Steven Y C TongDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Funding
Clinical Impact of the Cefazolin Inoculum EffectR01AI173138 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Cesar Augusto Arias · 2023 to 2026
$2.6MCIHR 433304CIHR 466322CIHR 474605Department of Health, Australian Government 2017301Health Research Council of New Zealand 20/344Medical Research Council MC_UU_00004/05National Health and Medical Research Council 1184238National Health and Medical Research Council 2014900National Health and Medical Research Council 2032628National Institute for Health Research 133719National Medical Research Council CTGIIT21nov-0002NIAID NIH HHS R01 AI173138NIH HHS 1R01AI173138-01A1Starship Foundation ASF2144_WEBBZonMw 10140022110014
Abstract
background
methodsIn an ongoing international Bayesian adaptive platform trial, we conducted an open-label, randomized comparison of cefazolin with an antistaphylococcal penicillin (flucloxacillin or cloxacillin) in adult patients with penicillin-resistant, methicillin-susceptible
resultsThis domain of the ongoing trial was conducted between February 17, 2022, and August 7, 2024, by which time the criterion for noninferiority had been met. Mortality at 90 days among adults who could be evaluated was 15.0% (97 deaths among 645 patients) in the cefazolin group and 17.0% (109 deaths among 642 patients) in the antistaphylococcal-penicillin group (adjusted odds ratio, 0.81; 95% credible interval, 0.59 to 1.12; probability of noninferiority, 99.2%; probability of superiority, 89.8%). Acute kidney injury occurred in 92 of 660 patients (13.9%) in the cefazolin group, as compared with 127 of 648 (19.6%) in the antistaphylococcal-penicillin group (adjusted odds ratio, 0.67; 95% credible interval, 0.50 to 0.89; probability of superiority, 99.7%).
conclusionsIn patients with methicillin-susceptible
Indexed as
Acute Kidney InjuryBacteremiaCefazolinCloxacillinFloxacillinStaphylococcal InfectionsStaphylococcus aureusAgedAnti-Bacterial AgentsBayes TheoremFemaleFirst Generation CephalosporinsHumansIncidenceMaleMiddle AgedAnti-Bacterial AgentsCefazolinCloxacillinFirst Generation CephalosporinsFloxacillin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.