Evidence map›Paper›PMID 42308311›Full record

ArticleScience advances2026

Piezobiomimetic delivery nanosystem converts cold tumors to hot by parallel PANoptosis/STING activation in hepatocellular carcinoma.

Jiaoting E, Yuxuan Zhao, Xiaoling Zhang, Qiuqi Zhang, Ying Xu, Shanshan Liu, He Ding, Jiuxin Zhu, Piaoping Yang, Rui Xie

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaoting EDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, P. R. China.ORCID 0009-0000-0134-3775
Yuxuan ZhaoKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.ORCID 0009-0000-5388-5146
Xiaoling ZhangDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, P. R. China.ORCID 0000-0002-4835-8648
Qiuqi ZhangDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, P. R. China.ORCID 0009-0009-8706-0156
Ying XuDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, P. R. China.ORCID 0009-0000-5039-507X
Shanshan LiuDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, P. R. China.ORCID 0009-0001-8570-7763
He DingKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.ORCID 0000-0002-2371-5119
Jiuxin ZhuDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150086, P. R. China.ORCID 0000-0003-4215-4502
Piaoping YangKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.ORCID 0000-0002-9555-1803
Rui XieDepartment of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, P. R. China.ORCID 0000-0003-0357-6702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) remains a challenge for therapeutic efficacy in converting cold tumors into hot ones. Herein, doping defect-engineered manganese perovskite piezoelectric nanocubes (Mn-BaZrO

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMembrane ProteinsNanoparticlesNecroptosisAnimalsApoptosisCell Line, TumorcGAS-STING Signaling PathwayHumansMiceReactive Oxygen SpeciesSTING ProteinMembrane ProteinsReactive Oxygen SpeciesSTING1 protein, humanSTING Protein

Identifiers

PMID42308311
PMCPMC13274619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.