Evidence map›Paper›PMID 42308310›Full record

ArticleScience advances2026

NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription.

Avery A Ahmed, Tessa E Steenwinkel, Bethany K Patton, Peixin Jiang, Matthew D Meyer, Jaspreet K Rishi, Mei Leng, Alexander B Saltzman, Elizabeth S Anaya, Momal Sharif and 5 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Avery A AhmedDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6040-7166
Tessa E SteenwinkelDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3949-930X
Bethany K PattonDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1739-0338
Peixin JiangDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0005-8033-1639
Matthew D MeyerShared Equipment Authority, Rice University, Houston, TX, USA.ORCID 0000-0002-0680-6123
Jaspreet K RishiDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0000-3021-0875
Mei LengMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-7231-8665
Alexander B SaltzmanMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-4166-9555
Elizabeth S AnayaDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8164-921X
Momal SharifDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8876-9946
Laurie J McKenzieDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
Laura DettiDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-6868-7185
Anna MalovannayaMass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-2953-6485
Sean M HartigDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2695-2072
Stephanie A PangasDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5748-5844

Funding

Comprehensive Mechanisms in Reproductive SciencesT32HD098068 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI STEPHANIE A. PANGAS · 2020 to 2026
$2.4M
A functional neddylation pathway underlies oocyte quality and agingR21HD109807 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI PANGAS, STEPHANIE A. · 2022 to 2023
$440k
NICHD NIH HHS R21 HD109807NICHD NIH HHS T32 HD098068
6 · The paper itself

Abstract

Age-related decline in oocyte quality increases the risk of infertility, miscarriage, and birth defects. Mitochondrial dysfunction is a key contributor to this decline. Here, we report that oocyte-specific deletion of

Indexed as

MitochondriaNEDD8 ProteinOocytesTranscription, GeneticAnimalsDNA-Directed RNA PolymerasesFemaleHumansMiceMice, KnockoutMitochondrial ProteinsOxidative PhosphorylationReactive Oxygen SpeciesUbiquitinationDNA-Directed RNA PolymerasesMitochondrial ProteinsNEDD8 ProteinReactive Oxygen Species

Identifiers

PMID42308310
PMCPMC13274606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.