In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
20 authors.
Beisi XuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-0099-858X Laura J JankeDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-9871-6239 Gustavo PalaciosDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0009-0001-2483-3774 Clifford GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-7486-7107 Jeremy Chase CrawfordDepartment of Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0003-4096-6048 Yiping FanCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-8430-4620 Wojciech RosikiewiczCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-7031-3430 Hoang LeDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jacob A SteeleCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-9924-2226 Shondra M Pruett-MillerCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-3793-585X Yong ChengDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0003-2042-9974 Terrence GeigerDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-8290-5732 Yongqiang FengDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-2320-5063 Funding
Epigenetic Checkpoint Regulation of Naive T-cell Quiescence and Peripheral ToleranceR01AI187465 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHENG, YONG, FENG, YONGQIANG · 2025 to 2025
$3.4MRobust immune tolerance conferred by Foxp3 transcriptional regulationR01AI153138 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2021 to 2025
$2.2MDetermination of chromatin protein dynamics in CD8 T cellsR21AI173909 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2023 to 2024
$501kIdentify novel modulators of regulatory T cell function from the dynamic cis-proteomesR21AI163942 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2021 to 2022
$494kNIAID NIH HHS R01 AI153138NIAID NIH HHS R01 AI187465NIAID NIH HHS R21 AI163942NIAID NIH HHS R21 AI173909
6 · The paper itselfAbstract
Peripheral tolerance depends on limiting conventional T cell responses to self-antigens. To define the contribution of nutritional factors and related epigenetic regulation, we perform in vivo CRISPR screening and identify the ascorbate transporter Slc23a2 as a key regulator of naive T cell (Tn) reactivity. T cell-specific loss of
Indexed as
Ascorbic AcidDioxygenasesDNA-Binding ProteinsPeripheral ToleranceProto-Oncogene ProteinsSodium-Coupled Vitamin C TransportersT-LymphocytesAnimalsCell DifferentiationDNA MethylationEpigenesis, GeneticHepatocyte Nuclear Factor 1-alphaMiceMice, KnockoutAscorbic AcidDioxygenasesDNA-Binding ProteinsHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseProto-Oncogene ProteinsSlc23a2 protein, mouseSodium-Coupled Vitamin C TransportersTET1 protein, mouse
Identifiers
PMID42308298
PMCPMC13274593
What OpenQuestion holds
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