Evidence map›Paper›PMID 42308292›Full record

ArticleScience advances2026

Noninvasive whole-brain imaging of glymphatic dynamics.

Nanchao Wang, Xinyuan Yu, Matthew Lowerison, Qinzhe Li, Aidan J Canning, Peibang He, Lihong Dang, Simone Degan, Brian Mace, Yirui Xu and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nanchao WangDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-5037-4145
Xinyuan YuDepartment of Anesthesiology, Duke University Medical Center, Durham, NC, USA.ORCID 0009-0005-9855-0207
Matthew LowerisonDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-1125-4554
Qinzhe LiDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0009-0004-0455-3830
Aidan J CanningDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-8001-6496
Peibang HeDepartment of Anesthesiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-6931-7722
Lihong DangDepartment of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Simone DeganDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-5417-1196
Brian MaceDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-5478-6227
Yirui XuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0009-0001-5694-3724
Rui YaoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0009-0000-3710-7387
Jingting LiDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Tianhua ZhouDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-3584-0785
Jinhuan LuoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Bing-Ze LinDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0001-7323-4236
Denis A TurnerDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-7118-0764
Xin LiuDepartment of Biomedical Engineering, Fudan University, Shanghai, China.ORCID 0000-0002-4783-9810
Dean TaDepartment of Biomedical Engineering, Fudan University, Shanghai, China.ORCID 0000-0001-6651-4491
Jonathan LovellDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-9052-884X
Tuan Vo-DinhDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0003-3701-3326
Wuwei FengDepartment of Neurology, Duke University School of Medicine, Durham, NC, USA.
Pengfei SongDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-9103-6345
Wei YangDepartment of Anesthesiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-5719-4393
Junjie YaoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-2381-706X

Funding

The Unfolded Protein Response in Ischemic StrokeR01NS099590 · NINDS · DUKE UNIVERSITY · PI Wei Yang · 2016 to 2026
$3.7M
Hypoperfusion, Hemodynamic Control Domains and Neurovascular Dysregulation in AD brain pathologyR01AG081774 · NIA · DUKE UNIVERSITY · PI DENNIS Alan TURNER · 2023 to 2026
$1.9M
Immunosuppression after cardiac arrest and resuscitationR01HL157354 · NHLBI · DUKE UNIVERSITY · PI YANG, WEI · 2022 to 2025
$1.6M
NHLBI NIH HHS R01 HL157354NIA NIH HHS R01 AG081774NINDS NIH HHS R01 NS099590
6 · The paper itself

Abstract

Cerebrospinal fluid circulation through the glymphatic system plays a crucial role in removing metabolic waste from the central nervous system. However, the mechanism underlying the brain-wide glymphatic dynamics is not yet fully understood, in part due to the lack of glymphatic imaging technologies on deep brains. Here, we report a hybrid imaging technology that integrates three-dimensional photoacoustic tomography and ultrasound localization microscopy (3D-PAULM), enhanced by a photoacoustic dye with strong optical absorption in the second near-infrared window (NIR-II). 3D-PAULM allows for continuous, noninvasive, whole-brain imaging in mice through intact skull, providing superresolution mapping of the brain vasculature and highly sensitive tracing of the NIR-II dye in the glymphatic system. Using 3D-PAULM, we investigated the glymphatic function impaired by ischemic stroke, aging, and anesthesia. Our results provide insights into glymphatic transport under various physiological as well as pathological conditions and establish 3D-PAULM as a valuable tool for preclinical glymphatic research.

Indexed as

BrainGlymphatic SystemAnimalsImaging, Three-DimensionalMicePhotoacoustic Techniques

Identifiers

PMID42308292
PMCPMC13274592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.