Evidence map›Paper›PMID 42308286›Full record

ArticleScience advances2026

Aptamer-functionalized apoptotic vesicles ameliorate osteoarthritis via resuming mitochondria OXPHOS of chondrocytes.

Zeying Wang, Yuhe Jiang, Xiuyun Xu, Yang Li, Ruiyi Guo, Ping Zhang, Yunsong Liu, Hao Liu, Jianlin Shen, Dan Lin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zeying WangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.ORCID 0000-0003-1606-9937
Yuhe JiangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.
Xiuyun XuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.
Yang LiDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.
Ruiyi GuoDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.
Ping ZhangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.
Yunsong LiuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.ORCID 0000-0001-8364-1898
Hao LiuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.
Jianlin ShenDepartment of Orthopaedics, Affiliated Hospital of Putian University, Putian 351100, Fujian, P. R. China.
Dan LinShanghai University of Medicine and Health Sciences, Shanghai 201318, P. R. China.ORCID 0000-0002-0159-7326
Xiao ZhangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.ORCID 0000-0002-5026-8692
Yongsheng ZhouDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 P. R. China.ORCID 0000-0002-4332-0878

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that osteoarthritis (OA) progression is critically associated with disruptions of cartilage matrix homeostasis caused by mitochondrial impairment in chondrocytes. Apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs) have exhibited great therapeutic promising for tissue regeneration and osteoarticular diseases. However, their poor ability targeting chondrocytes and short-time retention in joint cavity hinder further clinical translation. As a chemically synthesized nucleic acid, aptamer tgg2 demonstrated a robust specificity binding with chondrocytes. In this study, our team successfully functionalized apoVs with tgg2 (tgg2@apoVs) via Schiff base reaction with high conjugation efficiency and fabricated an injectable sustained-release system based on hyaluronic acid methacryloyl (HAMA) hydrogels. tgg2@apoVs significantly promoted chondrocyte extracellular matrix synthesis and improved mitochondrial oxidative phosphorylation (OXPHOS) in vitro. The HAMA injectable hydrogels compounded with tgg2@apoVs remarkedly alleviated OA symptoms in vivo. The potential molecular mechanism of apoVs' improvement in mitochondrial energy metabolism of chondrocytes is preliminarily investigated. Specifically, apoVs activate transcriptional factor Yin Yang 1 (YY1) to up-regulate the expression of Cox7c, a key subunit of complex IV in electron transport chain, thereby augmenting mitochondrial OXPHOS. In conclusion, the tgg2@apoVs' sustained-release system provides a cost-effective solution for OA treatment, and the elucidation of the molecular mechanism underlying apoVs' enhancement of chondrocyte OXPHOS offers insights for broader applications in energy metabolism-related diseases.

Indexed as

ApoptosisAptamers, NucleotideChondrocytesMitochondriaOsteoarthritisOxidative PhosphorylationAnimalsHumansHydrogelsMesenchymal Stem CellsAptamers, NucleotideHydrogels

Identifiers

PMID42308286
PMCPMC13274602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.