Evidence map›Paper›PMID 42308227›Full record

ArticleBlood advances2026

Class 3 MAP2K1 mutations associate with relapse and multiple treatment lines in multisystem Langerhans cell histiocytosis.

Kevin D Hofer, Claire Seydoux, Florian Angst, Stefan Balabanov, Marco M Bühler, Priska Bützberger, Christian Clarenbach, Eli L Diamond, Zoran Erlic, Friedemann Honecker and 7 more

Abstract read
In one paragraph

Article in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kevin D HoferDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-8558-4599
Claire SeydouxDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-3263-086X
Florian AngstInstitute for Radiology and Nuclear Medicine, Zurich Waid City Hospital, Zurich, Switzerland.
Stefan BalabanovDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.
Marco M BühlerDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Priska BützbergerDepartment of Hematology and Oncology, Cantonal Hospital Baden, Baden, Switzerland.
Christian ClarenbachDepartment of Pneumology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-2158-2321
Eli L DiamondDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5456-5961
Zoran ErlicDepartment for Endocrinology and Diabetology and Clinical Nutrition, Cantonal Hospital Glarus, Glarus, Switzerland.ORCID 0000-0001-6953-9133
Friedemann HoneckerTumor and Breast Center Eastern Switzerland, St. Gallen, Switzerland.ORCID 0000-0002-3700-3577
Martin HüllnerInstitute of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-4849-3292
Pascal KälinDepartment for Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.
Claudia LangDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-0469-7661
Young-Lan SongDepartment of Hematology and Oncology, City Hospital Zurich, Zurich, Switzerland.
Rahel StiefelDepartment of Hematology and Oncology, City Hospital Zurich, Zurich, Switzerland.
Markus G ManzDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-4676-7931
Wiebke RöslerDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-0495-1674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42308227
PMCPMC13558231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.