Evidence map›Paper›PMID 42308041›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Mathematical modeling of

Jordan Snyder, Morten Andersen, Johanne Gudmand-Høyer, Morten Kranker Larsen, Vibe Skov, Lasse Kjær, Christina Schjellerup Eickhardt-Dalbøge, Trine A Knudsen, Christina Ellervik, Hans C Hasselbalch and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jordan SnyderDepartment of Science and Environment, Centre for Mathematical Modeling - Human Health and Disease, IMFUFA, Roskilde University, Roskilde 4000, Denmark.ORCID 0000-0002-1001-134X
Morten AndersenDepartment of Science and Environment, Centre for Mathematical Modeling - Human Health and Disease, IMFUFA, Roskilde University, Roskilde 4000, Denmark.
Johanne Gudmand-HøyerDepartment of Science and Environment, Centre for Mathematical Modeling - Human Health and Disease, IMFUFA, Roskilde University, Roskilde 4000, Denmark.ORCID 0000-0002-4972-0653
Morten Kranker LarsenDepartment of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.
Vibe SkovDepartment of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.ORCID 0000-0003-0097-7826
Lasse KjærDepartment of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.
Christina Schjellerup Eickhardt-DalbøgeDepartment of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.ORCID 0000-0002-0740-0555
Trine A KnudsenDepartment of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.
Christina EllervikDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0002-3088-4375
Hans C HasselbalchDepartment of Hematology, Zealand University Hospital, Roskilde 4000, Denmark.
Johnny T Ottesen *Department of Science and Environment, Centre for Mathematical Modeling - Human Health and Disease, IMFUFA, Roskilde University, Roskilde 4000, Denmark.ORCID 0000-0002-9786-0300
Thomas Stiehl *Department of Science and Environment, Centre for Mathematical Modeling - Human Health and Disease, IMFUFA, Roskilde University, Roskilde 4000, Denmark.ORCID 0000-0001-9686-9197

Funding

Lundbeck Foundation (Lundbeckfonden) R335-2019-2300
6 · The paper itself

Abstract

The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are a group of blood cancers characterized by overproduction of one or more types of blood cells, which can lead to thrombosis and other complications. MPNs develop slowly and are driven by a relatively small set of mutations in the hematopoietic stem cells (HSCs). Their slow development (over the course of decades) affords a unique opportunity to study their onset, but until recently few data have been available from individuals not yet showing overt disease. Thanks to the ambitious Danish General Suburban Population Study conducted in suburban Zealand, Denmark, we have identified a ([Formula: see text]) cohort of individuals harboring the most common driver mutation in MPN (namely

Indexed as

Janus Kinase 2Myeloproliferative DisordersAllelesCohort StudiesDenmarkHematopoietic Stem CellsHumansMutationJAK2 protein, humanJanus Kinase 2early detectionmathematical modelingmyeloproliferative neoplasms

Identifiers

PMID42308041
PMCPMC13291664

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.