Evidence map›Paper›PMID 42308035›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

SLC25A3 exports mitochondrial copper to metalate cytochrome

Mohammad Zulkifli, Ifrah Farid, Laura E Oldfather, Vinit C Shanbhag, Scot C Leary, Michael J Petris, Paul A Cobine, Vishal M Gohil

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Cuproptosis and the bioinorganic basis of copper-induced cell death.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  3. Review
  4. Copper, cuproptosis, and cancer: biology concepts of a novel cell death.Apoptosis : an international journal on programmed cell death · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad ZulkifliDepartment of Biochemistry and Biophysics, MS 3474, Texas A&M University, College Station, TX 77843.ORCID 0000-0002-9110-9508
Ifrah FaridDepartment of Biochemistry and Biophysics, MS 3474, Texas A&M University, College Station, TX 77843.
Laura E OldfatherDepartment of Biological Sciences, Auburn University, Auburn, AL 36849.
Vinit C ShanbhagDepartments of Biochemistry and Ophthalmology, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211.ORCID 0000-0002-6188-7421
Scot C LearyDepartment of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N5E5, Canada.ORCID 0000-0001-8488-7822
Michael J PetrisDepartments of Biochemistry and Ophthalmology, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211.ORCID 0000-0003-4162-1674
Paul A CobineDepartment of Biological Sciences, Auburn University, Auburn, AL 36849.
Vishal M GohilDepartment of Biochemistry and Biophysics, MS 3474, Texas A&M University, College Station, TX 77843.ORCID 0000-0002-9920-2563

Funding

Targeting vulnerabilities in copper metabolism in the development of cancer therapiesR01CA262664 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2021 to 2025
$2.3M
Novel roles of copper in adaptive responses to hypoxiaR01DK131190 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2021 to 2025
$2.1M
Mitochondrial Copper BiologyR35GM152102 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI Vishal Mahendrasingh Gohil · 2024 to 2026
$1.7M
HHS | NIH | National Cancer Institute (NCI) R01CA262664HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK131190HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM152102
6 · The paper itself

Abstract

Copper (Cu) is an essential cofactor for cytochrome

Indexed as

CopperCuproptosisElectron Transport Complex IVMitochondriaBiological TransportMitochondrial ProteinsCopperElectron Transport Complex IVMitochondrial Proteinscoppercuproptosiscytochrome c oxidaseelesclomolSLC25A3

Identifiers

PMID42308035
PMCPMC13291491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.