Trial reportJournal of the American Geriatrics Society2026
NegotiAge-An AI-Based Caregiver Negotiation Training: Results From the Multiphase Optimization Strategy (MOST) Trial.
Trial report in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04837937 (Negotiation Training to Optimize Caregiver Communication in Alzheimer's Disease), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Negotiation Training to Optimize Caregiver Communication in Alzheimer's Disease
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Authors and funding
10 authors.
Funding
Abstract
backgroundFamily caregivers experience conflicts in caring for people with Alzheimer's dementia (PWD; e.g., siblings disagreeing, advocating with providers, PWD refusing assistance). Subsequently, family caregivers experience frustration, burden, and stress. Furthermore, these caregivers rarely receive formal conflict resolution training to ameliorate these concerns. We developed NegotiAge-an artificial intelligence (AI)-based negotiation training intervention that teaches caregivers how to resolve conflicts and provides the opportunity to practice negotiating with online avatars in real-world conflicts. We sought to optimize the potency and test the early effect of NegotiAge on family caregivers following the multiphase optimization strategy (MOST). PARTICIPANTS, DESIGN,
settingNational randomized factorial trial of NegotiAge with family caregivers of PWD (> 65 years). Caregivers were randomized to one of eight conditions and variables/outcomes assessed at baseline and 1 month following NegotiAge. The mixed methods project used dependent sample t-tests (quantitative) and constant comparative analysis (qualitative).
resultsAcross 23 states, 125 family caregivers (mean-age 54 years, 77% female) completed the study. Participants experienced significantly less caregiver burden (-3.24, p < 0.002) and negative affect (-2.1, p < 0.0001) between baseline and 1 month following. Those receiving two or more exercises experienced further significant burden reduction (-5.28, p < 0.04). Qualitative analyses supported these findings: "There was a time when my mother was crying. Because of the training I was able to calm her."; "When we have a conflict, I focus on the interest of both of us-helped tremendously." In the month following, 54% (n = 67) of participants experienced conflicts and 74% (n = 93) applied skills learned. Among utilizers, there was a significant decrease in forcing behaviors (-1.24, p < 0.0001).
conclusionsNegotiAge, an AI-based negotiation training intervention, significantly reduced burden and improved negative affect among family caregivers. Engaging in more negotiation exercises further reduced burden. NegotiAge has the potential to improve the lives of caregivers and PWD. Further testing is needed to determine the direct impact on older adults and long-term effects.
trial registrationClinicalTrials.gov identifier: NCT04837937.
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