Evidence map›Paper›PMID 42307978›Full record

ArticleeLife2026

Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release.

Javier Emperador-Melero, Steven J Del Signore, Kevin M De León González, Pascal S Kaeser, Avital A Rodal

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Javier Emperador-Melero *Department of Neurobiology, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-1364-4935
Steven J Del Signore *Department of Biology, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0001-6007-9732
Kevin M De León GonzálezDepartment of Biology, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0003-1315-7798
Pascal S Kaeser *Department of Neurobiology, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-1558-1958
Avital A Rodal *Department of Biology, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0002-2051-8304

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Quantitative Neuroscience: Tools for Bridging Levels of AnalysisT32NS007292 · NINDS · BRANDEIS UNIVERSITY · PI GINA G TURRIGIANO · 1986 to 2026
$12.7M
Dissecting the assembly of vertebrate neurotransmitter release sites-Research Supplements to Promote Diversity in Health-Related ResearchR01MH113349 · NIMH · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$6.1M
Molecular Dissection of Active Zone Functions in Neurotransmitter ReleaseR01NS083898 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2014 to 2026
$5.9M
Organization and Function of the Periactive ZoneR01NS116375 · NINDS · BRANDEIS UNIVERSITY · PI Avital Adah Rodal · 2020 to 2026
$2.5M
Abberior 3D-STED microscope for super-resolution imagingS10OD034223 · OD · BRANDEIS UNIVERSITY · PI RODAL, AVITAL ADAH · 2023 to 2023
$1.2M
Molecular Mechanisms for Co‐Assembly of Endocytic and Exocytic Machineries at a SynapseR00NS129959 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Javier Emperador Melero · 2025 to 2026
$473k
Molecular Mechanisms for Co‐Assembly of Endocytic and Exocytic Machineries at a SynapseK99NS129959 · NINDS · HARVARD MEDICAL SCHOOL · PI EMPERADOR MELERO, JAVIER · 2023 to 2024
$226k
NIH HHS K99NS129959NIH HHS P40 OD018537NIH HHS R01MH113349NIH HHS R01NS083898NIH HHS R01NS116375NIH HHS S10 OD034223NIH HHS T32007292NIMH NIH HHS R01 MH113349NINDS NIH HHS K99 NS129959NINDS NIH HHS R00 NS129959NINDS NIH HHS R01 NS083898NINDS NIH HHS R01 NS116375NINDS NIH HHS T32 NS007292U.S. National Science Foundation NSF-DMR 2011846
6 · The paper itself

Abstract

In presynaptic nerve terminals, the endocytic apparatus rapidly restores synaptic vesicles after neurotransmitter release. Many endocytic proteins localize to the periactive zone, a loosely defined area adjacent to active zones. A prevailing model posits that recruitment of these endocytic proteins to the periactive zone is activity-dependent. We show that periactive zone targeting of endocytic proteins is largely independent of active zone machinery and synaptic activity. At mouse hippocampal synapses and

Indexed as

EndocytosisPresynaptic TerminalsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsDynaminsHippocampusMiceNerve Tissue ProteinsNeuromuscular JunctionSynaptic VesiclesVesicular Transport ProteinsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportamphiphysinDap160 protein, DrosophilaDrosophila ProteinsDynaminsendophilin A1 protein, mouseNerve Tissue ProteinsVesicular Transport Proteinscell biologyD. melanogasterendocytosisexocytosisexo–endocytic couplingmouseneurosciencesynaptic terminals

Identifiers

PMID42307978
PMCPMC13275065

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.