ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2026
Vaginal Bleeding and an Intra-Abdominal Mass in a Sprague-Dawley Rat (Rattus norvegicus).
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
A 2-year-old female Sprague-Dawley rat (Rattus norvegicus) presented with mild vaginal bleeding and no additional clinical signs. Physical examination revealed a firm intra-abdominal mass and unilateral renal enlargement. Diagnostic evaluation including CBC, serum chemistry, and CT identified neutrophilia, metabolic abnormalities, and a large abdominal mass causing displacement of abdominal organs. Differential diagnoses included urinary tract infection, reproductive tract disease, and neoplasia. Due to poor prognosis, humane euthanasia was performed. Necropsy and histopathology revealed uterine adenocarcinoma with pulmonary metastasis. Splenomegaly was also identified, consistent with disseminated large granular lymphocyte leukemia involvement. This case demonstrates that subtle clinical abnormalities in aged laboratory rats may represent severe disseminated neoplastic disease.
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