ArticleJACC. Case reports2026
Catastrophic Pediatric Stroke Following Attempted Transcatheter Ventricular Septal Defect Closure.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- When the Cure Injures: Lessons From a Catastrophic Stroke After Transcatheter VSD Closure.JACC. Case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriprocedural stroke is a rare but potentially catastrophic complication of pediatric cardiac catheterization. CASE SUMMARY: An 18-month-old girl with a perimembranous ventricular septal defect and progressive aortic valve prolapse underwent elective transcatheter closure. The procedure was abandoned after 2 unsuccessful device deployment attempts due to worsening aortic regurgitation and device instability. Two hours later, she developed acute neurological deterioration. Brain computed tomography demonstrated a large right hemispheric infarction combining mixed-density subdural collection, and uncal herniation. Emergency decompressive craniectomy with hematoma evacuation was performed. Evaluation for thrombophilia and coagulopathy was negative. DISCUSSION: Thromboembolism related to subtherapeutic anticoagulation, contrast-related neurotoxicity, and patient vulnerability in the setting of procedural complexity were considered the most plausible mechanism. TAKE-HOME MESSAGE: Strict anticoagulation monitoring, appropriate heparin dosing, careful contrast selection, and thoughtful patient selection are essential to improve the safety of pediatric transcatheter interventions.
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