ArticleMicrobiology spectrum2026
Genomic analysis of antimicrobial resistance and virulence among gram-negative bloodstream isolates from Lebanon.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The increasing prevalence of multidrug-resistant (MDR) gram-negative bacteria has reduced therapeutic options for bloodstream infections (BSIs) and complicates clinical management. In Lebanon, limited genomic surveillance has restricted insight into the molecular determinants underlying resistance and virulence in invasive pathogens. In this study, whole-genome sequencing was used to characterize antimicrobial resistance, mobilome composition, and virulence gene content among 24 gram-negative isolates recovered from BSIs. Six species were identified, including IMPORTANCE: This study presents a pilot whole-genome sequencing analysis of 24 gram-negative bloodstream isolates from a tertiary care hospital in Lebanon. By integrating phenotypic susceptibility testing with genomic, mobilome, and virulence analyses, it reveals marked species- and isolate-level diversity. Resistance and virulence determinants were found within specific genetic contexts rather than being uniformly linked to species or sequence types, underscoring the value of genome-based surveillance to inform antimicrobial stewardship and infection control strategies.
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