Evidence map›Paper›PMID 42307149›Full record

ArticleJACC. CardioOncology2026

Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis.

Brooke D'Mello, Neel Sheth, Ani Orchanian-Cheff, David Soave, Sagi Abelson, Minna Woo, Calvin Ke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. CardioOncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brooke D'MelloToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Medicine, Temerty Faulty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Neel ShethFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Ani Orchanian-CheffLibrary and Information Services, University Health Network, Toronto, Ontario, Canada.
David SoaveDepartment of Mathematics, Wilfred Laurier University, Waterloo, Ontario, Canada; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Sagi AbelsonOntario Institute for Cancer Research, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Minna WooToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Medicine, Temerty Faulty of Medicine, University of Toronto, Toronto, Ontario, Canada; Departments of Medicine, Immunology, and Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, Department of Medicine, University Health Network, Toronto, Ontario, Canada.
Calvin KeToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Medicine, Temerty Faulty of Medicine, University of Toronto, Toronto, Ontario, Canada; Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, Department of Medicine, University Health Network, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Electronic address: calvin.ke@utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cells. CH encompasses mosaic chromosomal alterations or somatic mutations in leukemia-driver genes (CH of indeterminate potential). Although CH has been associated with overall mortality, driven largely by cardiovascular disease, its links to individual cardiometabolic endpoints remain unclear.

objectivesThe aims of this study were to systematically quantify the associations of CH with incident myocardial infarction, stroke, cardiovascular mortality, and type 2 diabetes and to assess whether these associations differ according to CH driver gene.

methodsMEDLINE, Embase, Cochrane, and CENTRAL were searched from inception through June 2025 for observational studies reporting age-adjusted associations between CH and cardiometabolic outcomes in adults. Animal and phenome-wide association studies were excluded. Using random-effects models, HRs were generated for primary outcomes. The risk for bias was assessed using the Newcastle-Ottawa Scale.

resultsEighteen studies encompassing more than 650,000 individuals were included, with 1 study of participants with hematological malignancy. CH was associated with increased incidence of myocardial infarction (HR: 1.14; 95% CI: 1.00-1.29), stroke (HR: 1.12; 95% CI: 1.03-1.23), cardiovascular mortality (HR: 1.20; 95% CI: 1.07-1.36), and type 2 diabetes (HR: 1.20; 95% CI: 1.02-1.41). In driver gene analyses, TET2 mutations were associated with a higher hazard of stroke (HR: 1.41; 95% CI: 1.03-1.93) and ASXL1 mutations with cardiovascular mortality (HR: 2.22; 95% CI: 1.37-3.60).

conclusionsCH is associated with cardiometabolic outcomes and may exhibit heterogeneity across mutations and clinical phenotypes, supporting its role as a somatic genomic marker of cardiometabolic risk. However, cautious interpretation and further study are required, as CH definitions were heterogeneous. (Association of Clonal Hematopoiesis with Type 2 Diabetes and Cardiovascular Disease: A Systematic Review and Meta Analysis; CRD420251156288).

Indexed as

cardiovascular diseaseclonal hematopoiesisclonal hematopoiesis of indeterminate potentialcoronary artery diseasediabetesgeneticsischemic diseasemosaic chromosomal alterationstype 2 diabetes

Identifiers

PMID42307149
PMCPMC13282834

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.