ArticleActa paediatrica (Oslo, Norway : 1992)2026
Serum Creatinine Levels in Children With Down Syndrome: A Single-Centre Retrospective Study in Ireland.
Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Age- and sex-specific serum creatinine reference curves in children and adolescents with Down syndrome.European journal of pediatrics · 2026Article
- Rethinking Creatinine in Children With Down Syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the proportion of children with Down syndrome (DS) with creatinine levels above standard paediatric reference ranges in a single-centre Irish outpatient cohort.
methodsWe performed a retrospective cross-sectional study of children aged 0-16 years attending the DS Clinic at Children's Health Ireland, Tallaght, between June 2022 and June 2024. Children with known renal disease and acute results were excluded. Creatinine levels were analysed using age- and sex-specific reference ranges. The proportion with creatinine above the upper reference limit was compared with the expected proportion of 2.5% using a one-sided exact binomial test. Estimated glomerular filtration rate (eGFR) was calculated using the bedside Schwartz equation, where height was available.
resultsA total of 194 patients were included. Among them, 52 (26.8%) had creatinine levels above the upper reference limit (p < 0.0001). Additionally, 42 (21.6%) had persistently elevated creatinine (p < 0.0001). Height was available for 124 children. Of those, 42 (34%) had an eGFR < 90 mL/min/1.73 m
conclusionChildren with DS in this Irish clinic frequently had creatinine levels above standard reference ranges. Further studies are required to clarify the clinical significance of these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.