Evidence map›Paper›PMID 42307013›Full record

ArticleACS infectious diseases2026

Synthesis and Evaluation of Nitroheterocyclic Aromatic Adamantanohydrazones with Trypanocidal Activity. Part III.

Angeliki-Sofia Foscolos, Konstantina Stavropoulou, Nuno Santarém, Anabela Cordeiro da Silva, Martin C Taylor, Theodora Calogeropoulou, Andrew Tsotinis, Ioannis P Papanastasiou, John M Kelly, Susan Wyllie

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Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angeliki-Sofia FoscolosDivision of Pharmaceutical Chemistry Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15771, Greece.ORCID 0000-0001-8123-5060
Konstantina StavropoulouDivision of Pharmaceutical Chemistry Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15771, Greece.
Nuno SantarémHost-Parasite Interaction Group, i3S, Institute for Research and Innovation in Health, University of Porto, Porto 4200-135, Portugal.
Anabela Cordeiro da SilvaHost-Parasite Interaction Group, i3S, Institute for Research and Innovation in Health, University of Porto, Porto 4200-135, Portugal.
Martin C TaylorLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.ORCID 0000-0003-4147-0693
Theodora CalogeropoulouInstitute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.ORCID 0000-0002-3369-5393
Andrew TsotinisDivision of Pharmaceutical Chemistry Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15771, Greece.
Ioannis P PapanastasiouDivision of Pharmaceutical Chemistry Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15771, Greece.ORCID 0000-0001-6974-2561
John M KellyLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.ORCID 0000-0003-4305-5258
Susan WyllieFaculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, U.K.ORCID 0000-0001-8810-5605

Funding

Wellcome Trust
6 · The paper itself

Abstract

Extending our research on the design, synthesis, and pharmacological evaluation of antitrypanosomatid nitroheterocyclic aromatic adamantanes, we have identified hydrazone derivatives conjugated with 5-nitrothiophene that have submicromolar activity against trypanosomes. Key structural features, namely, the incorporation of the adamantane ring into the skeleton of the new compounds, the nature and the length of the hydrazone linker, and the nitroheterocycle moiety were evaluated to optimize both efficacy and safety profiles. It is also shown that these compounds function as prodrugs that are bioactivated by parasite-specific nitroreductase enzymes, primarily NTR-1. These findings suggest that nitroheterocyclic aromatic adamantanohydrazones represent promising candidates for further development as antitrypanosomal agents.

Indexed as

AdamantaneHydrazonesTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosoma cruziAnimalsMolecular StructureNitroreductasesProdrugsStructure-Activity RelationshipAdamantaneHydrazonesNitroreductasesProdrugsTrypanocidal Agents(1-phenyl)adamantane(2-phenyl)adamantane5-nitrofuran-5-nitroimidazole-5-nitrothiophene-phenylacetohydrazones probesnitroreductase 1 (NRT-1)

Identifiers

PMID42307013
PMCPMC13366580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.