Evidence map›Paper›PMID 42306997›Full record

ArticleOrganic & biomolecular chemistry2026

Creating molecular complexity in the chemoenzymatic synthesis of chlorothricin analogues using tandem Diels-Alderases.

Andrew J Devine, Monserrat Manzo-Ruiz, Catherine R Back, Katja Zorn, Martin A Hayes, Paul R Race, Christine L Willis

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew J DevineSchool of Chemistry, University of Bristol, Bristol, BS8 1TS, UK. chris.willis@bristol.ac.uk.ORCID 0000-0002-4200-5542
Monserrat Manzo-RuizSchool of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK. paul.race1@newcastle.ac.uk.ORCID 0000-0003-2049-1487
Catherine R BackSchool of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.ORCID 0000-0002-9835-9171
Katja ZornCompound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, SE-431 83, Mölndal, Sweden.ORCID 0000-0001-5529-6484
Martin A HayesCompound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, SE-431 83, Mölndal, Sweden.ORCID 0000-0002-2640-8464
Paul R RaceSchool of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK. paul.race1@newcastle.ac.uk.ORCID 0000-0003-0184-5630
Christine L WillisSchool of Chemistry, University of Bristol, Bristol, BS8 1TS, UK. chris.willis@bristol.ac.uk.ORCID 0000-0002-3919-3642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chlorothricin is a polyketide-derived natural product isolated from

Indexed as

AminoglycosidesBiocatalysisCrystallography, X-RayCycloaddition ReactionModels, MolecularMolecular StructureNaphthalenesStreptomyces antibioticusAminoglycosideschlorothricinNaphthalenes

Identifiers

PMID42306997
PMCPMC13273814

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.