Evidence map›Paper›PMID 42306962›Full record

ArticleThe Journal of physiology2026

The influence of metaboreflex activation on pulmonary pressure with combined chemoreflex activation in acute and chronic hypoxia.

Lauren E Maier, Elliott J Jenkins, Andrew Douglas, Jack Talbot, Alexandra Williams, Jonathan Moore, Craig D Steinback, Liam D Corr, Zoe H Adams, Fabio Giuseppe Laginestra and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lauren E MaierCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, UK.ORCID https://orcid.org/0009-0009-9416-966X
Elliott J JenkinsCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, UK.ORCID https://orcid.org/0000-0002-4053-2410
Andrew DouglasCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, UK.ORCID https://orcid.org/0000-0003-2965-6081
Jack TalbotCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, UK.ORCID https://orcid.org/0000-0003-0234-1426
Alexandra WilliamsCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.ORCID https://orcid.org/0000-0003-1571-9168
Jonathan MooreInstitute for Applied Human Physiology, Department of Sport and Exercise Sciences, School of Psychology and Sports Science, College of Medicine and Health, Bangor University, Bangor, Wales, UK.ORCID https://orcid.org/0000-0002-4244-8220
Craig D SteinbackNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Liam D CorrCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, UK.ORCID https://orcid.org/0000-0001-7439-1372
Zoe H AdamsCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, UK.ORCID https://orcid.org/0000-0003-0187-0123
Fabio Giuseppe LaginestraDepartment of Anaesthesiology, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0003-4767-7249
Markus AmannDepartment of Anaesthesiology, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0002-4012-8880
Philip N AinslieCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada.ORCID https://orcid.org/0000-0001-6560-222X
Travis D GibbonsDepartment of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA.
Mike StembridgeCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, UK.ORCID https://orcid.org/0000-0003-0818-6420

Funding

Role of Sensory Neurons in Human Cardiovascular DiseaseR01HL116579 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2021
$3.4M
Autonomic Dysfunction in Patients with HFpEFR01HL162856 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2023 to 2026
$2.7M
Cardiovascular and neuromuscular issues in chronic painR01HL170007 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2024 to 2026
$2.3M
Heart and Stroke Foundation of CanadaMitacsNatural Sciences and Engineering Research Council of Canada 06637NHLBI NIH HHS HL-116579NHLBI NIH HHS HL-162856NHLBI NIH HHS R01 HL116579NHLBI NIH HHS R01 HL162856NHLBI NIH HHS R01 HL170007RRD VA I01 RX003343U.S. Veterans Affairs Rehabilitation Research and Development
6 · The paper itself

Abstract

Sympathetic activation arising from both the peripheral chemoreflex in hypoxia and muscle metaboreflex during exercise mediate an increase in pulmonary artery systolic pressure (PASP). We tested the hypothesis that coactivation of the chemoreflex and metaboreflex would augment the PASP response, as has been shown previously for heart rate and ventilation. We conducted two experimental studies: (i) a laboratory study (n = 15) in normoxia and acute isocapnic hypoxia (45 mmHg

Indexed as

high altitudehypoxiahypoxic pulmonary vasoconstrictionmetaboreflexpulmonary artery

Identifiers

PMID42306962
PMCPMC13587138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.