Evidence map›Paper›PMID 42306805›Full record

ArticleJournal of mood and anxiety disorders2026

Positive childhood experiences relate to prenatal mental health symptoms and diagnoses independent of childhood maltreatment.

Jessica A Marino, Angela Narayan, Anna M Zhou, Ella-Marie P Hennessey, Jenalee R Doom, Benjamin L Hankin, Elysia Poggi Davis

Abstract read
In one paragraph

Article in Journal of mood and anxiety disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica A MarinoDepartment of Psychiatry, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Angela NarayanDepartment of Psychology, University of Denver, Denver, CO, USA.
Anna M ZhouDepartment of Psychiatry, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Ella-Marie P HennesseyDepartment of Psychology, University of Denver, Denver, CO, USA.
Jenalee R DoomDepartment of Psychology, University of Denver, Denver, CO, USA.
Benjamin L HankinDepartment of Psychology, University of Illinois, Urbana-Champaign, Champaign, IL, USA.
Elysia Poggi DavisDepartment of Psychology, University of Denver, Denver, CO, USA.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2013 to 2023
$25.4M
Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk MechanismsR01MH109662 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, HANKIN, BENJAMIN L · 2017 to 2021
$4.0M
Reducing maternal prenatal depression to improve child cardiovascular healthR01HL155744 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, DOOM, JENALEE RAE · 2021 to 2025
$3.6M
Inflammatory trajectories across pregnancy: Investigating novel markers of risk for postpartum depressionR21MH124026 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, HANKIN, BENJAMIN L · 2021 to 2022
$426k
NHLBI NIH HHS R01 HL155744NIMH NIH HHS P50 MH096889NIMH NIH HHS R01 MH109662NIMH NIH HHS R21 MH124026NIMH NIH HHS T32 MH015442
6 · The paper itself

Abstract

Purpose: Prenatal mental health problems often impair maternal functioning and offspring development. Maternal childhood maltreatment is a well-established risk factor for prenatal mental health problems; however, growing evidence supports the health-promoting role of positive childhood experiences (PCEs) for better prenatal mental health. Yet joint effects of childhood maltreatment and PCEs on prenatal mental illness diagnoses, in addition to symptoms, are not understood. Methods: This study examined associations between childhood maltreatment and PCEs on prenatal mental health symptoms and clinical diagnoses in 234 pregnant individuals ( Results: Higher levels of childhood maltreatment predicted greater symptom levels of depression, anxiety, and PTSD during pregnancy (effect sizes: 0.17-0.23) and elevated of prenatal MDD and adult GAD (ORs: 1.31, 1.32). In contrast, higher levels of PCEs predicted less symptom severity across all domains (effect sizes: -0.31 to -0.38) and lower MDD and GAD rates (ORs: 0.68, 0.70). When maltreatment and PCEs were modeled simultaneously, PCEs were the only significant predictor of fewer symptoms and diagnoses across all domains (effect sizes: -0.29 to -0.35; ORs: 0.68, 0.70), whereas effects of childhood maltreatment dropped to non-significance. Conclusion: Positive childhood experiences have enduring effects, predicting both dimensional and categorical prenatal mental health above and beyond childhood maltreatment.

Indexed as

Childhood maltreatmentDevelopmental psychopathologyPositive childhood experiences (PCEs)Prenatal mental healthResilience

Identifiers

PMID42306805
PMCPMC13267695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.