Evidence map›Paper›PMID 42306765›Full record

ArticleJournal of thoracic disease2026

Downregulation of

Zhen-Yu Hu, Wei-Hao Deng, Jun-Xiu Huang, Zhe Li, Yu-Zhen Zheng, Hong-Ying Liao

Abstract read
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhen-Yu Hu *Department of Thoracic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wei-Hao Deng *Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jun-Xiu HuangDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Zhe LiDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yu-Zhen ZhengDepartment of Thoracic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Hong-Ying LiaoDepartment of Thoracic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Esophageal squamous cell carcinoma (ESCC) is a prevalent gastrointestinal malignancy in China and is associated with a poor prognosis and limited therapeutic options. Methods: Bioinformatics analysis was performed using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) datasets. Meanwhile, EZR protein expression in clinical ESCC tissues and paired adjacent normal tissues was determined by immunohistochemistry (IHC) and further validated in ESCC cell lines via Western blotting and quantitative real-time polymerase chain reaction (qRT-PCR). Stable Results: Conclusions:

Indexed as

EGFResophageal squamous cell carcinoma (ESCC)EZRfocal adhesion

Identifiers

PMID42306765
PMCPMC13266804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.