Evidence map›Paper›PMID 42306736›Full record

ArticleJournal of thoracic disease2026

Clinical characteristics, symptom burden, and pulmonary function trajectories of spirometry- and MMEF-defined bronchodilator responsiveness in COPD: a single-center prospective study.

Zhaoqian Gong, Junrao Wang, Meijia Chen, Xueying Zhao, Junwen Huang, Ying Chen, Yuling Hu, Hailun Huang, Wenqu Zhao, Jianpeng Liang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhaoqian Gong *Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Junrao Wang *Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Meijia Chen *Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xueying ZhaoChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Junwen HuangChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ying ChenChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yuling HuChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hailun HuangChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wenqu ZhaoChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianpeng LiangChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Haijin ZhaoChronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bronchodilator responsiveness (BDR) is a common indicator in chronic obstructive pulmonary disease (COPD), but its clinical relevance remains controversial. Traditional spirometry may fail to detect small airway reversibility, which can be captured by maximum mid-expiratory flow (MMEF). The clinical significance of combined-BDR (integrating spirometric indices and MMEF) in guiding phenotype-based and individualized COPD management under current Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations remains unclear. This study aimed to investigate the clinical significance of combined-BDR in patients with COPD. Methods: In this single-center prospective study, a total of 137 patients with stable COPD were enrolled [post-bronchodilator forced expiratory volume in one second (FEV Results: Of 137 patients, 49 (35.8%) exhibited Combined-BDR, while 88 (64.2%) did not. Baseline demographic characteristics, including age, sex, body mass index (BMI), smoking status, and fractional exhaled nitric oxide (FeNO) levels, were comparable between the two groups. Patients with combined-BDR had significantly higher mMRC scores (P<0.01), CAT total scores (11.73±6.29 Conclusions: Combined-BDR identifies a distinct COPD phenotype characterized by a higher baseline symptom burden but greater functional improvement following inhaled therapy, highlighting its potential value for phenotype-guided and individualized disease management.

Indexed as

Bronchodilator responsiveness (BDR)forced expiratory volume in one second (FEV1)forced vital capacity (FVC)maximum mid-expiratory flow (MMEF)outcomes

Identifiers

PMID42306736
PMCPMC13266835

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.