ArticleJournal of thoracic disease2026
Pressurized intrathoracic aerosol chemotherapy (PITAC) for malignant pleural mesothelioma-
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Malignant pleural mesothelioma (MPM) is a rare but aggressive disease with poor prognosis and limited treatment options. Pressurized intrathoracic aerosol chemotherapy (PITAC) has emerged as a novel approach for intrathoracic drug delivery. The aim of this study was to investigate cisplatin penetration characteristics and to evaluate procedural parameters influencing drug penetration, including temperature, drug concentration and pleural barrier function, in an Methods: We investigated the penetration depth and intensity of aerosolized cisplatin generated using a high-pressure nebulizer in an Results: A temperature of 42 ℃, a cisplatin concentration of 1 mg/mL, and prior removal of the pleura, improved the penetration depth and intensity of the chemotherapeutic agent. Under clinically relevant experimental conditions, aerosolized cisplatin application demonstrated greater tissue penetration compared to HITOC. Conclusions: Our preclinical data suggest that PITAC may be a viable alternative to HITOC and warrants further clinical investigation.
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