ArticleJournal of thoracic disease2026
Monitoring pneumonia onset and severe respiratory infectious diseases using quantitative computed tomography, validation amidst the coronavirus disease 2019 outbreak at the end of 2022 in the Chinese mainland.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Effective surveillance of severe respiratory infectious diseases is crucial. This study aimed to explore an automated quantitative analysis method based on chest computed tomography (CT) for distinguishing individuals with pneumonia and to evaluate its effectiveness for monitoring pneumonia incidence. Methods: Hospitalized pneumonia patients and healthy controls with normal chest CTs were enrolled. CT images were analyzed using "uAI Discover Pneumonia" software (United Imaging Intelligence) to derive CT-derived quantitative metrics related to pneumonia, including total lung infection volume and proportion of infected lung volume relative to total lung volume. Differences in these quantitative CT (QCT) infection metrics between the two groups were compared. The cutoff value with the highest Youden index was selected and its sensitivity and specificity were evaluated. CT scans requested from pneumonia-related emergency departments and outpatient departments (PR-ED/OPD) between Week 27, 2022, and Week 26, 2023 were extracted. Chest CT request volume was counted. The proportion of pneumonia-positive CT scans and the estimated pneumonia patients volume within these requests were calculated weekly to reflect temporal changes in pneumonia incidence. These indicators were compared with other surveillance metrics using cross-correlation analysis to evaluate temporal relationships. The proportion of pneumonia-positive CT scans and estimated pneumonia patient volume were compared across typical periods following policy changes. Results: A total of 209 pneumonia patients and 221 control subjects were included. The median [interquartile range (IQR)] total lung infection volume was 545.1 (255.7-966.7) mL in the pneumonia group and 0.0 (0.0-13.1) mL in the non-pneumonia control group (P<0.001). Median infected volume proportion was 19.90% (7.15-33.85%) Conclusions: CT-derived quantitative metrics exhibit excellent diagnostic accuracy for pneumonia, with recommended cutoffs of ≥65 mL total infected volume and ≥1.75% infected proportion. This automated method effectively monitors pneumonia incidence, reflecting the epidemic status of severe respiratory infections.
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