ArticleJournal of thoracic disease2026
Impact of surgical margins on treatment outcomes in pulmonary resections for
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Pulmonary resection is an important adjunct to antifungal therapy in selected patients with Aspergillus-related lung disease. However, the impact of surgical margin status on treatment outcomes remains poorly defined. The objective is to compare the impact of surgical margins on treatment response in patients with pulmonary fungal infections, analyzing persistence of symptoms, perpetuation of fungal colonization, and disease recurrence. Methods: This retrospective study analyzed patients treated between 2020 and 2024 with inflammatory/infectious pulmonary diseases caused by Results: Nineteen patients were included, of whom four experienced disease recurrence. All recurrence cases occurred in the "tangential margin" group. Tangential margins were strongly associated with symptom persistence, with an odds ratio (OR) of 11.0 [95% confidence interval (CI): 1.30-140.9, P=0.04]. Patients in this group also showed a smaller reduction in Conclusions: As lung-sparing surgeries become more prevalent, an adequate surgical margin remains critical to achieving disease-free survival. This study suggests the importance of ensuring sufficient margins in pulmonary resections for fungal infections to optimize therapeutic outcomes. Additional research is needed to confirm our findings.
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