ArticleFrontiers in neurology
A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The prognostic value of vitamin-related biomarkers in acute ischemic stroke (AIS) remains incompletely defined. This study evaluated associations between serum vitamin-related markers and 3-month functional outcome and developed an internally validated nomogram for individualized risk prediction. Methods: Consecutive AIS patients admitted to Huludao Central Hospital between November 2024 and July 2025 were retrospectively included ( Results: Among 655 patients, 346 (52.82%) had poor outcomes and 309 (47.18%) had good outcomes at 3 months. Multivariable analysis identified vitamin D, vitamin E, vitamin A, vitamin K1, vitamin B12, folate, and homocysteine as independent predictors of poor outcome. The nomogram showed good discrimination, with an AUC of 0.878 in the training set and 0.880 in the test set, together with favorable calibration and decision-curve performance. In the test set, both the vitamin-based model and the combined model outperformed the clinical baseline model (AUC 0.884 and 0.886 vs. 0.734; DeLong Conclusion: This serum vitamin-related biomarker nomogram may assist early risk stratification for 3-month functional outcome after AIS. However, as this was a single-center retrospective study with internal validation only, the model should be regarded as preliminary and requires external multicenter validation and prospective evaluation of clinical impact in patient management and outcomes before routine clinical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.