Evidence map›Paper›PMID 42306575›Full record

ArticleResearch in pharmaceutical sciences2026

Effects of pomegranate seed extract and ellagic acid on miR-16-5p and miR-34a-5p expression, cell cycle, and apoptosis in MCF-7 cells.

Zahra Sadeghi, Mohammadreza Sharifi, Mehrnoush Malekzadeh, Sho'leh Ghaedamini, Batool Hashemibeni

Abstract read
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In one paragraph

Article in Research in pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zahra SadeghiDepartment of Anatomical Sciences and Reproductive Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammadreza SharifiDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mehrnoush MalekzadehDepartment of Anatomical Sciences and Reproductive Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Sho'leh GhaedaminiDepartment of Anatomical Sciences and Reproductive Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Batool HashemibeniDepartment of Anatomical Sciences and Reproductive Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: The expression of Experimental approach: MCF-7 cells were encapsulated in 3-D alginate scaffolds and cultured (experimental groups: EA, PSE, EA and PSE, and the control group). Cell viability (using MTT assay), cell apoptosis Findings/Results: The combination of PSE and EA exhibited the greatest effects on MCF-7 cells. EA and PSE increased the expression of Conclusion and implications: EA and PSE antioxidants increased

Indexed as

Breast cancerEllagic acidhsa-miR-16-5phsa-miR-34a-5pPomegranate seed extract.

Identifiers

PMID42306575
PMCPMC13268002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.