Evidence map›Paper›PMID 42306535›Full record

ArticleFrontiers in cellular and infection microbiology2026

Salivary exosomal

Jun Ma, Xubin Zheng, Yifan He, Xuewen Tang, Zhen Huang, Li Wang, Xing Tang, Yuanyuan Huang, Zhizhi Lei, Min Zhu and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jun Ma *Department of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xubin ZhengClinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yifan He *Department of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xuewen Tang *Shanghai Liquidbio Bio-tech Co., Ltd., Shanghai, China.
Zhen HuangCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA, United States.
Li WangDepartment of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xing TangShanghai Liquidbio Bio-tech Co., Ltd., Shanghai, China.
Yuanyuan HuangShanghai Liquidbio Bio-tech Co., Ltd., Shanghai, China.
Zhizhi LeiShanghai Liquidbio Bio-tech Co., Ltd., Shanghai, China.
Min ZhuShanghai Liquidbio Bio-tech Co., Ltd., Shanghai, China.
Wei ShaDepartment of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-sputum-based tools are essential complements to the current tuberculosis diagnosis strategy. We aim to determine whether dual-gene qPCR melting curve detection of salivary exosomes Methods: We developed the exosomal nucleic acid (ExoNA)-based saliva tuberculosis diagnostic, a rapid, non-sputum diagnostic method for tuberculosis by integrating enrichment of salivary exosomes, nucleic acid extraction, and dual-target qPCR melting curve analysis. In a pilot clinical study, adults with suspected pulmonary tuberculosis were enrolled to evaluate diagnostic performance against multiple reference standards. Subgroup analysis was performed in patients with negative smear microscopy. Results: Salivary exosomal DNA was identified as the predominant form of detectable Conclusion: ExoNA-based saliva tuberculosis assay demonstrates favorable diagnostic performance in patients with suspected pulmonary tuberculosis, with the advantages of non-invasive nature, easy sampling, and rapid detection. Multicenter validation in more heterogeneous populations is necessary prior to clinical use.

Indexed as

DNA, BacterialExosomesMolecular Diagnostic TechniquesMycobacterium tuberculosisSalivaTuberculosis, PulmonaryAdultAgedBacilloscopyFemaleHumansMaleMiddle AgedPilot ProjectsReal-Time Polymerase Chain ReactionSensitivity and SpecificityDNA, Bacterialexosomemolecular diagnosispaucibacillary tuberculosisqPCRsaliva

Identifiers

PMID42306535
PMCPMC13265331

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.