Evidence map›Paper›PMID 42306525›Full record

ArticleFrontiers in cellular and infection microbiology2026

Goatpox virus Hrf-063 interacts with host eIF4A1 and is associated with altered expression of antiviral signaling-related factors.

Baoqin Long, Huixiang Wang, Linjin Yu, Bo Liu, Mengjiao Xu, Haerleha Amantai, Weiqian Tian, Haoran Chen, Haolai Qin, Yahui Han and 6 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Baoqin LongCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Huixiang WangCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Linjin YuCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Bo LiuCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Mengjiao XuCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Haerleha AmantaiCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Weiqian TianCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Haoran ChenCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Haolai QinCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Yahui HanCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Longxing ShiCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Jingxin GuCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Mingxuan TangCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Zhiyi GeCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Jia ChenCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.
Youwen LiCollege of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps, Alaer, Xinjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Goatpox virus (GTPV) is an important capripoxvirus that causes severe disease in goats, yet the functions of many GTPV-encoded proteins remain unclear. In this study, eukaryotic translation initiation factor 4A1 (eIF4A1) was identified as a host protein interacting with GTPV Hrf-063 by GST pull-down combined with LC-MS/MS analysis. This interaction was further confirmed by reciprocal pull-down assays and co-immunoprecipitation in mammalian cells. Domain-mapping analysis showed that the N-terminal region of Hrf-063 and amino acids 211-330 of eIF4A1 were critical for their interaction, and confocal microscopy demonstrated that both proteins predominantly co-localized in the cytoplasm. Functional analyses showed that Hrf-063 was negatively associated with eIF4A1 expression during GTPV infection, while eIF4A1 modulation affected the expression of the GTPV virulence-associated protein Klp2. In addition, perturbation of Hrf-063 or eIF4A1 altered the expression of STAT1 and CAV1, and Hrf-063 regulated ISG15 and STING1 transcription in a time- and infection-dependent manner. TCID

Indexed as

CapripoxvirusEukaryotic Initiation Factor-4AHost-Pathogen InteractionsViral ProteinsAnimalsCell LineGoatsHumansProtein BindingSignal TransductionVirus ReplicationEukaryotic Initiation Factor-4AViral Proteinsantiviral signalingCapripoxviruseIF4A1goatpox virushost-virus interactionHrf-063viral replication

Identifiers

PMID42306525
PMCPMC13265270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.