ArticleIranian journal of microbiology2026
Genetic variations on influenza virus infection outcomes in Moroccan patients.
Article in Iranian journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objectives: The influenza infection remains a significant global health challenge, it leads to illnesses that vary from mild to severe, and in certain cases, death. The innate immune response is the first line of defense against pathogen invaders; identification of variants associated with susceptibility or protection could further elucidate immune mechanisms and provide the basis for new therapeutic targets. Materials and Methods: We investigated four widely studied SNPs on the immune response to RNA infection in samples collected as part of sentinel influenza surveillance system. Of 1925 nasopharyngeal swabs collected from patients with Severe Acute Respiratory Infection (SARI) and Influenza-Like Illness (ILI), 115 samples were positive for ILI and 83 were positive for SARI. A third group of healthy individuals was also enrolled as a control. Genetic polymorphisms of the Results: The Conclusion: Our results open up a new perspective for new methods and strategies of therapy aimed to enhance the body's natural defenses against influenza virus infection.
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