ArticleInternational journal of women's health2026
Decreased CD8+ T Lymphocytes is an Independent Influencing Factor for Persistent HR-HPV Infection.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the characteristics of vaginal microecological changes and peripheral blood immune cell subset levels in patients with high-risk human papillomavirus (HR-HPV) infection, and to identify independent risk factors for persistent HR-HPV infection, so as to provide a reference for clinical prevention and treatment of cervical lesions. Methods: A total of 165 participants admitted to Ningde Mindong Hospital from January 2021 to December 2022 were enrolled in this single-center observational study, including 49 cases with persistent HR-HPV positivity and 116 cases with transient HR-HPV infection. Vaginal microecological indicators (cleanliness, pH, bacterial vaginosis score, hydrogen peroxide, sialidase) and peripheral blood immune cell subsets were detected to analyse. Results: Compared with the transient HR-HPV infection group, the persistent infection group showed significant vaginal microecological imbalance, including lower proportion of grade I-II vaginal cleanliness, higher BV score ≥4, lower proportion of pH ≤4.5, and higher positive rates of hydrogen peroxide and sialidase (all P<0.05). In addition, in the present study, sialidase was also significantly increased in the group with cytological and pathological results ≥HSIL (P<0.05). The percentages of CD4+ T lymphocytes and CD8+ T lymphocytes in the persistent infection group were significantly decreased (P<0.05), while there were no significant differences in T lymphocytes, B lymphocytes, and NK cells between the two groups (P>0.05). Multivariate Logistic regression analysis showed that decreased CD8+ T lymphocytes was an independent risk factor for persistent HR-HPV infection (P<0.05). Conclusion: Persistent HR-HPV infection is closely associated with vaginal microecological imbalance and impaired cellular immune function. This exploratory study confirms that decreased CD8+ T lymphocytes is independently associated with persistent HR-HPV infection. Comprehensive assessment of vaginal microecological status and CD8+ T lymphocyte level may help identify high-risk populations, but the clinical predictive value needs to be verified by large-sample prospective studies.
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