Evidence map›Paper›PMID 42306465›Full record

ArticleJournal of vascular anomalies2022

Primary Upper Extremity Lymphedema Caused by a

Christopher L Sudduth, Patrick J Smits, Yu Sheng Cheng, Klaus Schmitz-Abe, Pankaj Agrawal, Arin K Greene

Abstract read
In one paragraph

Article in Journal of vascular anomalies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher L SudduthDepartment of Plastic and Oral Surgery, Lymphedema ProgramBoston Children's Hospital, Harvard Medical School, Boston, MA.
Patrick J SmitsDepartment of Plastic and Oral Surgery, Lymphedema ProgramBoston Children's Hospital, Harvard Medical School, Boston, MA.
Yu Sheng ChengDepartment of Plastic and Oral Surgery, Lymphedema ProgramBoston Children's Hospital, Harvard Medical School, Boston, MA.
Klaus Schmitz-AbeDivisions of Newborn Medicine and Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Pankaj AgrawalDivisions of Newborn Medicine and Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Arin K GreeneDepartment of Plastic and Oral Surgery, Lymphedema ProgramBoston Children's Hospital, Harvard Medical School, Boston, MA.

Funding

Pediatric Surgeon-Scientist Training Program in Vascular DiseasesT32HD104582 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Joyce E. Bischoff, Arin K. Greene · 2022 to 2026
$1.1M
NICHD NIH HHS T32 HD104582
6 · The paper itself

Abstract

Primary lymphedema of the upper extremity is rare and often is associated with syndromic or generalized lymphedema. The purpose of the study was to identify novel causes for primary lymphedema of the arm. A 17 year-old healthy male with right upper extremity swelling since infancy was confirmed to have lymphedema by lymphoscintigraphy. He subsequently developed right leg disease in adolescence and his mother had lower extremity lymphedema as well. Whole-exome sequencing of genomic DNA from the subject identified a frameshift deletion resulting in a premature stop codon in exon 3 of the

Indexed as

armCELSR1lymphedemaprimaryvariant

Identifiers

PMID42306465
PMCPMC13267888

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.