Effects of increasing respiratory rate on ventilatory efficiency and mechanical costs during low-tidal-volume ventilation: a prospective physiological pilot study.

Carolin Jung, Erietta Markou, Kai Florian Storch, Jona Wassong, Hans-Joerg Gillmann, Thomas Stueber

Abstract read

In one paragraph

Article in Annals of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Carolin JungDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Erietta MarkouDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Kai Florian StorchDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Jona WassongDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Hans-Joerg GillmannDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Thomas StueberDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: During lung-protective ventilation, respiratory rate (RR) is frequently increased to compensate for hypercapnia. Despite its widespread use, however, the physiological consequences of this strategy remain incompletely understood. We aimed to characterize the physiological trade-offs of stepwise RR escalation at fixed tidal volume during controlled ventilation, with a particular focus on dead space partitioning, ventilatory efficiency, and energetic burden. Methods: In this prospective physiological crossover pilot study, 30 mechanically ventilated ICU patients underwent stepwise RR increases from 15 to 33 min Results: A 50% increase in minute ventilation (RR 17→25 min Conclusions: In this physiological study, RR escalation during low-tidal volume ventilation was associated with progressive decline in ventilatory efficiency, driven by increasing dead space fraction and compounded by rising CO

Indexed as

Dead spaceMechanical ventilationRespiratory physiologyRespiratory rateVentilatory efficiency

Identifiers

PMID42306311

DOI10.1016/j.aicoj.2026.100098

PMCPMC13266209

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