ArticleFrontiers in cell and developmental biology2026
Human pluripotent stem cell-derived neuroepithelial cells develop into an organizer for optic tectum formation in the chicken diencephalon.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human brain development critically depends on the formation of secondary organizers, which determine specification of neural territories along the antero-posterior axis. Studies on human secondary organizers have proven to be difficult due to technical limitations and ethical concerns. Here, using interspecies transplantations we demonstrate that neuroepithelial cells (NECs) derived from human pluripotent stem cells (hPSCs) acquire properties of the isthmic organizer (IsO) when transplanted into the HH11 chicken anterior diencephalon, driving formation of a fully laminated optic tectum. hPSCs-derived NECs initially do not express the whole range of characteristic IsO molecules, but develop these features after transplantation and interaction within host tissue. We show that engineered human NECs act as dominant IsOs, overriding local signals in the chicken diencephalon to form a mesencephalic architecture, the optic tectum. The generation of IsOs from hPSCs offers new opportunities to study the pathogenesis of brain defects caused by malfunctions of the IsO.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.