Evidence map›Paper›PMID 42306267›Full record

ArticleJTCVS structural and endovascular2026

The heterogeneous nature of atrioventricular conduction tissues in tetralogy of Fallot demonstrated by hierarchical phase-contrast tomography.

Vaishnavi Sabarigirivasan, Joseph Brunet, Hector Dejea, Adrian Crucean, Anusha Jegatheeswaran, Claudio Capelli, Endrit Pajaziti, Theresa Urban, Joanna Purzycka, Paul Tafforeau and 3 more

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Article in JTCVS structural and endovascular, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Vaishnavi SabarigirivasanInstitute of Cardiovascular Sciences, University College London, London, United Kingdom.
Joseph BrunetDepartment of Mechanical Engineering, University College London, London, United Kingdom.
Hector DejeaEuropean Synchrotron Radiation Facility, Grenoble, France.
Adrian CruceanBirmingham Children's Hospital, Birmingham, United Kingdom.
Anusha JegatheeswaranGreat Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Claudio CapelliInstitute of Cardiovascular Sciences, University College London, London, United Kingdom.
Endrit PajazitiGreat Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Theresa UrbanDepartment of Mechanical Engineering, University College London, London, United Kingdom.
Joanna PurzyckaEuropean Synchrotron Radiation Facility, Grenoble, France.
Paul TafforeauEuropean Synchrotron Radiation Facility, Grenoble, France.
Claire L WalshDepartment of Mechanical Engineering, University College London, London, United Kingdom.
Peter D LeeDepartment of Mechanical Engineering, University College London, London, United Kingdom.
Andrew C CookInstitute of Cardiovascular Sciences, University College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Postoperative arrhythmias are frequent after tetralogy of Fallot (ToF) repair, yet anatomic substrate and preventive strategies remain poorly defined. Using hierarchical phase-contrast tomography (HiP-CT), the atrioventricular conduction system in pediatric ToF specimens was investigated nondestructively and in 3-dimensions (3D). Methods: Eighteen whole-heart specimens (11 ToF, 7 controls) were imaged at the European Synchrotron Radiation Facility. Segmentation and 3D renderings demonstrated gross morphology. Morphology, size, depth, and course of the nonbranching bundle and right bundle branch (RBB) were quantified using custom computational pipelines. Segmentations were visualized in VheaRts, a Unity3D-based XR platform. Results: The ToF conduction system was more draped than in controls, bilaterally spanning the septum, resembling early embryonic architecture. The RBB was variable in origin, course, and morphologic structure with significantly smaller indexed cross-sectional area in native ToF versus controls (0.05 ± 0.20 vs 0.50 ± 0.20 mm Conclusions: This first pediatric cardiac HiP-CT series reveals a broader anomalous conduction complex in ToF, including variable RBB origin and hypoplasia, providing insight into preoperative vulnerability, arrhythmia, and surgical risk.

Indexed as

arrhythmiaHiP-CTright bundle branchtetralogy of Fallot

Identifiers

PMID42306267
PMCPMC13244724

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.