ArticleFrontiers in allergy2026
Effect of deep inspiration on impulse oscillometry responses to methacholine in healthy adults.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Impulse oscillometry (IOS) detects small-airway hyperresponsiveness during methacholine challenge testing (MCT). Deep inspiration (DI) may attenuate these responses, but the magnitude and interpretive impact of this effect in healthy adults remain uncertain. Methods: We conducted a prospective two-period crossover study in 38 healthy, non-smoking adults (median age 34.8 years; 53% female). Each participant completed two standardized five-dose MCT protocols: (i) IOS-only and (ii) IOS immediately followed by spirometry (IOS + DI). The primary endpoint was the within-subject difference in total resistance at 5 Hz ( Results: No participant met the PD₂₀FEV₁ criterion. At the final dose, the IOS-only protocol elicited larger responses than IOS + DI (median Conclusion: Deep inspiration substantially attenuates methacholine-induced IOS responses, underscoring the need for protocol-specific diagnostic thresholds. IOS-only MCT provides sensitive, effort-independent information and may be particularly valuable when spirometry is impracticable.
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