Evidence map›Paper›PMID 42306170›Full record

ArticleCurrent opinion in behavioral sciences2021

Brain activity is not only for thinking.

Timothy O Laumann, Abraham Z Snyder

Abstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Trial
  2. Article
  3. A Hitchhiker's Guide to Physical and Cognitive Effort.Sports medicine (Auckland, N.Z.) · 2026
    Review
  4. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Aging and the Spectral Properties of Brain Hemodynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Spatiotemporal Patterns in Cortical Development: Age, Puberty, and Individual Variability from 9 to 13 Years of Age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Article
  14. Structure-function coupling in the first month of life: Associations with age and attention.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
  16. Brain-wide dynamic coactivation states code for hand movements in the resting state.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Measuring neuroplasticity in human development: the potential to inform the type and timing of mental health interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Timothy O LaumannDepartment of Psychiatry, Washington University in St. Louis School of Medicine, United States.
Abraham Z SnyderDepartment of Neurology, Washington University in St. Louis School of Medicine, United States.

Funding

IMAGING COREP01NS080675 · NINDS · WASHINGTON UNIVERSITY · PI RAICHLE, MARCUS E · 2013 to 2017
$6.2M
NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G, MARCUS, DANIEL SCOTT · 2016 to 2019
$2.4M
Washington University Psychiatry Residency Research Education ProgramR25MH112473 · NIMH · WASHINGTON UNIVERSITY · PI NURI B FARBER, Timothy Eric Spiegel · 2018 to 2026
$1.6M
NIMH NIH HHS R25 MH112473NINDS NIH HHS P01 NS080675NINDS NIH HHS P30 NS098577
6 · The paper itself

Abstract

The human brain is a complex organ with multiple competing imperatives. It must perceive and interpret the world, incorporate new information, and maintain its functional integrity over the lifespan. Neural activity is associated with all of these processes. Spontaneous BOLD signals have been invoked as representing neural activity associated with all of these processes. However, their exact role in these processes remains controversial. Here, we review learning machine theory, molecular mechanisms of synaptic plasticity and homeostasis, and recent experimental evidence to suggest that spontaneous BOLD activity may be more closely aligned with off-line plasticity and homeostatic processes than on-line fluctuations in cognitive content.

Identifiers

PMID42306170
PMCPMC13268537

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.