Evidence map›Paper›PMID 42306114›Full record

ReviewLe infezioni in medicina2026

Imported Leishmaniasis in Europe (2000-2024): A systematic review of travel-related case reports.

Sandra M Alcocer-Veintimilla, Víctor A Pillajo-Gangotena, Jaime David Acosta-España, Aula Abbara, Marta González-Sanz, Alfonso J Rodriguez-Morales

Abstract readReview
In one paragraph

Review in Le infezioni in medicina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra M Alcocer-Veintimilla *School of Medicine, Health Sciences Faculty, Universidad Internacional SEK del Ecuador, Quito, Ecuador.
Víctor A Pillajo-Gangotena *School of Medicine, Health Sciences Faculty, Universidad Internacional SEK del Ecuador, Quito, Ecuador.
Jaime David Acosta-EspañaMicrobiology, Infectious Diseases and Travel Medicine Department, Health Sciences Faculty, Universidad Internacional SEK (UISEK), Quito, Ecuador.
Aula AbbaraFaculty of Medicine, Imperial College London, St Mary's Hospital, London, United Kingdom.
Marta González-SanzNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain.
Alfonso J Rodriguez-MoralesFaculty of Health Sciences, Universidad Científica del Sur, Lima, Perú.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This review aims to systematically analyze imported leishmaniasis cases reported between 2000 and 2024, focusing on geographic origin, host demographics, clinical manifestations, diagnostic approaches, and species distribution. Methods: A systematic review was conducted in accordance with the PRISMA guidelines across PubMed, Scopus, and Web of Science. Inclusion criteria encompassed case reports and series in English or Spanish that described laboratory-confirmed human leishmaniasis acquired outside of Europe. The risk of bias was assessed using the JBI Critical Appraisal Tool. Data was extracted and analyzed using RStudio (v4.3.1) for statistical exploration, including subgroup analysis and temporal trends. The protocol was registered in PROSPERO (CRD420251128116). Results: Twelve studies documenting 127 published cases were reviewed, mainly from Germany, Spain, Poland, and Austria. The most common form was cutaneous leishmaniasis (63%), followed by mucocutaneous (27%) and visceral (10%). Visceral leishmaniasis was significantly linked to lower odds of being a tourist (OR: 0.24; 95% CI: 0.07-0.87; p = 0.027). Diagnostic methods varied, including PCR, histology, and microscopy. The main species were Conclusions: The importation of leishmaniasis in Europe highlights a growing health challenge. Diagnostic variability, underreporting, and limited clinician awareness cause delays and mismanagement. Enhancing surveillance, standardizing diagnostics, and adding pre-travel advice to routine care are vital. Future research should focus on species resistance, coinfections, and long-term effects for better guidelines.

Indexed as

EuropeLeishmaniaLeishmaniasissystematic reviewtourismtravel medicine

Identifiers

PMID42306114
PMCPMC13267958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.