ArticleFrontiers in human neuroscience2026
Association of neurite orientation dispersion and density imaging with cognitive impairment in nasopharyngeal carcinoma patients with radiation-induced temporal lobe injury.
Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To evaluate whether neurite orientation dispersion and density imaging (NODDI) can reflect cognitive impairment (CI) in nasopharyngeal carcinoma (NPC) patients with late-delayed radiation-induced temporal lobe injury (RTLI). Methods: In this prospective study, 90 NPC patients with RTLI underwent structural MRI, conventional diffusion-weighted imaging, and NODDI. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA; score < 26 indicated CI). NODDI-derived parameters-intra-neurite volume fraction (ICVF), isotropic volume fraction (ISOVF), and orientation dispersion index (ODI)-and apparent diffusion coefficient (ADC) were compared between patients with and without CI. Diagnostic performance and correlations with MoCA scores were analyzed. Results: Among 90 patients, 66 had CI. CI patients exhibited significantly lower ICVF and ODI ( Conclusion: NODDI-derived ICVF is associated with CI and correlates with MoCA scores in NPC patients with RTLI.
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