ReviewCureus2026
Arthrocentesis Plus Injectable Platelet-Rich Fibrin in Patients With Temporomandibular Joint Dysfunction: An Updated Meta-Analysis With Trial Sequential Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporomandibular joint (TMJ) dysfunction (TMD) is a common disorder associated with chronic pain, impaired mandibular movement, and reduced quality of life (QoL). Arthrocentesis is widely used as a minimally invasive treatment for symptomatic TMD; however, incomplete symptom resolution remains common. Injectable platelet-rich fibrin (i-PRF) has recently emerged as a biologic adjunctive therapy with potential regenerative and anti-inflammatory effects. Therefore, we conducted an updated systematic review and meta-analysis to evaluate the efficacy of arthrocentesis combined with i-PRF in patients with TMD. A comprehensive literature search was performed using PubMed, Scopus, Web of Science (WoS), and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to May 1, 2026. Randomized controlled trials (RCTs) comparing arthrocentesis plus i-PRF with control interventions were included. The primary outcome was the change in pain score measured using the Visual Analogue Scale (VAS). Secondary outcomes included maximum mouth opening (MMO), lateral excursion, protrusive movement, and QoL. Pooled estimates were calculated using a random-effects model and expressed as mean differences (MDs) with 95% confidence intervals (CIs). Nine RCTs involving 320 patients (374 joints) were included. Arthrocentesis combined with i-PRF significantly reduced pain scores compared with control interventions (MD -1.62, 95% CI: -2.28 to -0.96; p<0.001; I
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