ReviewFrontiers in medicine2026
Ultraviolet radiation as a double-edged regulator of melanocyte function in vitiligo therapy and melanoma carcinogenesis.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanistic Insights into Phytocompounds for Vitiligo Therapy: Current Evidence and Future Opportunities.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitiligo is a chronic autoimmune disorder characterized by selective melanocyte loss and progressive depigmentation. Narrowband ultraviolet B (NB-UVB) and excimer-based phototherapy are widely regarded as standard treatments in clinical practice and remain the most effective approaches for inducing repigmentation. However, excessive or uncontrolled ultraviolet radiation (UVR) exposure can impair skin barrier function, cause melanocyte dysfunction, and increase the risk of photoaging and carcinogenesis. This apparent paradox arises from the bidirectional biological effects of UVR: on the one hand, UVR activates melanocytes and promotes skin pigmentation through coordinated effects on melanocyte maturation, proliferation, and melanin synthesis, while on the other hand, UVR can induce oxidative stress, DNA damage, apoptosis, and genomic instability. Therefore, combination strategies incorporating JAK inhibitors, platelet-rich plasma, or cellular grafting techniques have been increasingly explored in clinical practice. In this review, we provide an integrated perspective on the dual effects of UVR on melanocyte biology, discuss emerging combination therapies for vitiligo, and highlight the mechanistic links between phototherapy, melanocyte homeostasis, and melanoma risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.