ArticleJournal of hepatocellular carcinoma2025
Lobar Yttrium-90 Radioembolization with BSA-Based Dosimetry for Unresectable Hepatocellular Carcinoma: Baseline Vascularity Predicts Responders to the Combination with Targeted Therapy or Immune Checkpoint Inhibition.
Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This retrospective study investigates the benefit of combining lobar radioembolization (TARE), performed using a body surface area (BSA) dose prescription model, with targeted therapy (TT) in hepatocellular carcinoma (HCC), and aims to identify predictors of response through contrast-enhanced MRI tumour volumetry. Methods: Ninety-two HCC patients who underwent TARE at our center between 10/2008 and 01/2022 and a baseline MRI within 60 days prior to TARE as well as follow-up MRI were included. Pre- and post-treatment target lesion volumes were measured as total-tumour-volume (TTV) and enhancing-tumour-volume (ETV). Kaplan-Meier analysis, Log rank tests, and Cox regression were used to assess the impact of clinical and imaging variables on time to target lesion progression and overall survival. Results: The mean patient age was 65 (SD 10) years; 67 patients had liver cirrhosis. Median overall survival (mOS) was 13 months (95% CI 11-16). A baseline ETV/TTV ratio >50% was associated with a median ETV reduction of 41% versus a 61% increase in those with low vascularity (p<0.001), and a longer time to target lesion progression (28 vs 3 months, p=0.002). Of 45 patients receiving TT, 21 were treated within 2 months before TARE. In this subgroup with pre-interventional TT, high vascularity correlated with significantly improved mOS (>17 vs 6 months, p=0.027), while no survival difference was observed in other cohorts. Conclusion: High baseline vascularization may help identify patients who benefit from conventional lobar TARE and a narrowly timed combination with TT in terms of mOS, suggesting synergistic effects in patients not eligible for resection or ablation.
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