ArticleFrontiers in bioengineering and biotechnology2026
Adenosine as a modulator of human islet function and hypoxic tolerance.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effect of Adenosine on the Morphological and Functional Integrity of Isolated Human Islets Exposed to Normoxic and Hypoxic Conditions.Bioengineering (Basel, Switzerland) · 2026Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Islet transplantation hold promises as a cell therapy for managing type 1 diabetes, but its effectiveness remains limited due to early graft loss caused by hypoxia and associated stressors. Identifying strategies to enhance islet resilience is imperative for improving clinical outcomes. We hypothesized that mitigating this injury requires shifting focus from augmenting oxygen supply to reducing the cellular metabolic demand. Adenosine (AD), an endogenous purine nucleoside with immunomodulatory and metabolic regulatory roles, emerges as a candidate to mitigate these challenges. This study evaluates the impact of AD on human islet (HI) viability, function, and metabolic suppression under hypoxic stress (1% O
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