Evidence map›Paper›PMID 42305724›Full record

ArticleJournal of oral microbiology2026

Capsaicin inhibits cariogenic

Xinyan Huang, Jianhang Bao, Jiaqi Zhu, Shuangyue Wu, Yuankun Zhai, Yanfang Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinyan HuangDepartment of Dentistry, School of Stomatology, Henan University, Kaifeng, China.
Jianhang BaoDepartment of Dentistry, School of Stomatology, Henan University, Kaifeng, China.
Jiaqi ZhuDepartment of Dentistry, School of Stomatology, Henan University, Kaifeng, China.
Shuangyue WuDepartment of Dentistry, School of Stomatology, Henan University, Kaifeng, China.
Yuankun ZhaiDepartment of Dentistry, School of Stomatology, Henan University, Kaifeng, China.
Yanfang RenDepartment of Dentistry, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This research aimed to determine whether capsaicin (CAP), a phytochemical in chilli peppers, inhibits cariogenic Design: The anti-caries potential of CAP was assessed in Results: CAP inhibited the growth of both organisms (MIC = 320 µg/mL). At 1/2 MIC (160 µg/mL) and MIC, CAP significantly suppressed biofilm formation, disrupted pre-formed biofilms and decreased acid production and extracellular polysaccharide (EPS) accumulation. In mature biofilms, CAP downregulated key virulence genes associated with EPS biosynthesis ( Conclusion: CAP attenuated key virulence attributes of

Indexed as

biofilmCandida albicansCapsaicindental cariesStreptococcus mutans

Identifiers

PMID42305724
PMCPMC13267022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.