Evidence map›Paper›PMID 42305625›Full record

ArticleiScience2026

Genetic inactivation of Translin/Trax RNase disrupts miRNAs, hippocampal synaptic plasticity, and memory.

Mahesh Shivarama Shetty, Junko Kasuya, Xiuping Fu, Marisol Carmela Lauffer, Satya Murthy Tadinada, Tania Chatterjee Chowdhury, Zeru Peterson, Knute D Carter, Jay M Baraban, Ted Abel

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahesh Shivarama ShettyDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA.
Junko KasuyaDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA.
Xiuping FuThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA.
Marisol Carmela LaufferIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA 52242, USA.
Satya Murthy TadinadaDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA.
Tania Chatterjee ChowdhuryDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA.
Zeru PetersonIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA 52242, USA.
Knute D CarterDepartment of Biostatistics, College of Public Health, University of Iowa, 145 N. Riverside Drive, Iowa City, IA 52242, USA.
Jay M BarabanThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe St, Baltimore, MD 21205, USA.
Ted AbelDepartment of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurons utilize RNA interference in the reversible translational repression of synaptically localized mRNAs, enabling rapid translation in response to synaptic activity. Two evolutionarily conserved proteins, Translin and Trax, form an RNase complex that processes miRNAs, tRNAs, and siRNAs. To determine the specific role of the RNase activity of this complex in brain function, we employed a mouse line harboring a point mutation in Trax (E126A) that renders the Translin/Trax RNase inactive. At the molecular level, we found alterations in the levels of multiple small RNAs, including miRNAs, tsRNAs, and substantial downregulation of gene expression at the mRNA level in the hippocampus of TraxE126A mice. At the synaptic level, TraxE126A mice exhibit deficits in specific forms of long-term hippocampal synaptic plasticity. At the behavioral level, TraxE126A mice display impaired long-term spatial memory and altered open-field behavior. These studies reveal the functional role of Translin/Trax RNase in the mammalian brain.

Indexed as

geneticsmolecular biologyneuroscienceomics

Identifiers

PMID42305625
PMCPMC13266039

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.