Evidence map›Paper›PMID 42305619›Full record

ArticleiScience2026

RNF213 isoform 2 restricts Zika virus through antiviral signaling and viral protein degradation.

Xiaoyu Yang, Teng Chen, Bin Ren, Jinqiu Liu, Zhen Xu, Jingyi Wang, Yiran Shi, Lihua Liu, Lili Li, Genhong Cheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoyu YangDepartment of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Teng ChenKey Laboratory of Jilin Province for Zoonoses Prevention and Control, State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Changchun 130122, China.
Bin RenSenior Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Jinqiu LiuState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.
Zhen XuDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Jingyi WangDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Yiran ShiDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Lihua LiuSchool of Basic Medicine, Gannan Medical University, Ganzhou 341000, China.
Lili LiGuangzhou National Laboratory, Guangzhou 510005, China.
Genhong ChengGuangzhou National Laboratory, Guangzhou 510005, China.
Dongming ZhouDepartment of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Qi ChenState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.
Shulong ZuDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin 300070, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several RING finger (RNF) family proteins exert antiviral effects primarily by regulating host antiviral pathways. Moreover, the longer isoform of RNF213 can also directly target viral proteins to inhibit infection. However, the antiviral potential of the shorter isoform of RNF213 (RNF213 isoform 2) remains unexplored. Here, we report that RNF213 isoform 2 (hereafter referred to as RNF213) activates the retinoic acid-inducible gene I (RIG-I)-melanoma differentiation-associated gene 5 (MDA5) pathway and promotes proteasomal and lysosomal degradation of multiple Zika virus (ZIKV) proteins, including the capsid (C), envelope (E), nonstructural 3 (NS3), and nonstructural 4B (NS4B) proteins, to restrict ZIKV infection. Notably, we identified a 23-amino acid peptide (PR-23) derived from RNF213 that degrades ZIKV proteins and suppresses viral replication

Indexed as

biochemistryvirology

Identifiers

PMID42305619
PMCPMC13266186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.