ReviewiScience2026
Biological Determinants and non-pharmacological management of orthodontic pain.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthodontic pain remains a significant barrier to patient compliance, affecting up to 95% of individuals. This review provides a comprehensive analysis of the multifactorial nature of this pain, encompassing demographic, systemic, intraoral, and treatment-related variables. Furthermore, the paper critically evaluates a spectrum of management strategies beyond traditional pharmacotherapy, assessing their clinical efficacy and quality of evidence. Based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework, non-pharmacological alternatives show varying levels of support: low-level laser therapy (LLLT) and chewing therapy are backed by moderate-certainty evidence, whereas vibration and emerging psychological interventions currently rely on low-certainty evidence. By identifying key research gaps in optimizing these modern therapies, the review emphasizes the urgent need for larger, highly standardized clinical trials to develop personalized, evidence-based pain management protocols and improve the patient experience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.