ArticleiScience2026
The development of residential gut microbiota in mice at different phases in early life.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Gut microbiota develops to an adult-like mode in early life and stays comparatively stable since then. There are 3 stages in early life: delivery, breastfeeding, and post-weaning nutrition period. In our study, we ascertained the forming of adult-like microbiota pattern in early life time by establishing antibiotic-treated mice model and analyzed the residential microorganism of whole gastrointestinal tract using 16S rRNA sequencing. The antibiotic-treated mouse model showed antibiotics could influence gut bacterial development and breastfeeding is the critical period for gastric and ileal microbiota development. In this study, we were the first to investigate the residential bacteria in the whole gastrointestinal tract in early life time. With our approach of exploration of gut microbiota evolution, we hope to provide a better view of how residential microflora develop in early life and influence the future gut microbial system, which help us better understand gut microbiota and related diseases.
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